Establishment of normal gut microbiota is compromised under excessive hygiene conditions.

Bettina Schmidt; Imke E. Mulder; Corran C. Musk; Rustam Aminov; Marie Lewis; Christopher R. Stokes; Mick Bailey; James I. Prosser; Bhupinder P. Gill; John R. Pluske; Denise Kelly

doi:10.1371/journal.pone.0028284

Establishment of normal gut microbiota is compromised under excessive hygiene conditions.

Bettina Schmidt
, Imke E. Mulder
, Corran C. Musk
, Rustam Aminov
, Marie Lewis
, Christopher R. Stokes
, Mick Bailey
, James I. Prosser
, Bhupinder P. Gill
, John R. Pluske
, Denise Kelly

Research output: Contribution to journal › Journal article › Research › peer-review

49 Downloads (Orbit)

Abstract

The results documented here indicate that establishment and development of the normal gut microbiota requires continuous microbial exposure during the early stages of life and this process is compromised under conditions of excessive hygiene.

Original language	English
Article number	e28284
Journal	PloS one.
Volume	6
Issue number	12
Number of pages	10
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0028284
Publication status	Published - 2011
Externally published	Yes

Keywords

Animals
Biodiversity
Crosses, Genetic
Gastrointestinal Tract
Gene Library
Hygiene
Intestinal Mucosa
Metagenome
Phylogeny
RNA, Ribosomal, 16S
Sequence Alignment
Sequence Analysis, DNA
Swine

Access to Document

10.1371/journal.pone.0028284

JournalFinal published version, 415 KB

http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0028284&representation=PDF

OpenUrl availability

Full text

Cite this

@article{b3e515b0dcd942089f99966919d9e274,

title = "Establishment of normal gut microbiota is compromised under excessive hygiene conditions.",

abstract = "The results documented here indicate that establishment and development of the normal gut microbiota requires continuous microbial exposure during the early stages of life and this process is compromised under conditions of excessive hygiene.",

keywords = "Animals, Biodiversity, Crosses, Genetic, Gastrointestinal Tract, Gene Library, Hygiene, Intestinal Mucosa, Metagenome, Phylogeny, RNA, Ribosomal, 16S, Sequence Alignment, Sequence Analysis, DNA, Swine",

author = "Bettina Schmidt and Mulder, \{Imke E.\} and Musk, \{Corran C.\} and Rustam Aminov and Marie Lewis and Stokes, \{Christopher R.\} and Mick Bailey and Prosser, \{James I.\} and Gill, \{Bhupinder P.\} and Pluske, \{John R.\} and Denise Kelly",

year = "2011",

doi = "10.1371/journal.pone.0028284",

language = "English",

volume = "6",

journal = "PloS one.",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "12",

}

TY - JOUR

T1 - Establishment of normal gut microbiota is compromised under excessive hygiene conditions.

AU - Schmidt, Bettina

AU - Mulder, Imke E.

AU - Musk, Corran C.

AU - Aminov, Rustam

AU - Lewis, Marie

AU - Stokes, Christopher R.

AU - Bailey, Mick

AU - Prosser, James I.

AU - Gill, Bhupinder P.

AU - Pluske, John R.

AU - Kelly, Denise

PY - 2011

Y1 - 2011

N2 - The results documented here indicate that establishment and development of the normal gut microbiota requires continuous microbial exposure during the early stages of life and this process is compromised under conditions of excessive hygiene.

AB - The results documented here indicate that establishment and development of the normal gut microbiota requires continuous microbial exposure during the early stages of life and this process is compromised under conditions of excessive hygiene.

KW - Animals

KW - Biodiversity

KW - Crosses, Genetic

KW - Gastrointestinal Tract

KW - Gene Library

KW - Hygiene

KW - Intestinal Mucosa

KW - Metagenome

KW - Phylogeny

KW - RNA, Ribosomal, 16S

KW - Sequence Alignment

KW - Sequence Analysis, DNA

KW - Swine

U2 - 10.1371/journal.pone.0028284

DO - 10.1371/journal.pone.0028284

M3 - Journal article

SN - 1932-6203

VL - 6

JO - PloS one.

JF - PloS one.

IS - 12

M1 - e28284

ER -

Establishment of normal gut microbiota is compromised under excessive hygiene conditions.

Abstract

Keywords

Access to Document

OpenUrl availability

Fingerprint

Cite this