Establishment of normal gut microbiota is compromised under excessive hygiene conditions.

Bettina Schmidt, Imke E. Mulder, Corran C. Musk, Rustam Aminov, Marie Lewis, Christopher R. Stokes, Mick Bailey, James I. Prosser, Bhupinder P. Gill, John R. Pluske, Denise Kelly

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The results documented here indicate that establishment and development of the normal gut microbiota requires continuous microbial exposure during the early stages of life and this process is compromised under conditions of excessive hygiene.
Original languageEnglish
Article numbere28284
JournalPloS one.
Issue number12
Number of pages10
Publication statusPublished - 2011
Externally publishedYes


  • Animals
  • Biodiversity
  • Crosses, Genetic
  • Gastrointestinal Tract
  • Gene Library
  • Hygiene
  • Intestinal Mucosa
  • Metagenome
  • Phylogeny
  • RNA, Ribosomal, 16S
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Swine

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