Establishment of cumulative assessment groups of pesticides for their effects on the nervous system

European Food Safety Authority (EFSA)

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Cumulative assessment groups of pesticides have been established for five effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, functional alterations of the motor, sensory and autonomic divisions, and histological neuropathological changes in neural tissue. Sources of uncertainties resulting from the methodological approach and from the limitations in available data and scientific knowledge have been identified and considered. This report supports the publication of a scientific report on cumulative risk assessment to pesticides affecting the nervous system, in which all uncertainties identified for either the exposure assessment or the establishment of the cumulative assessment groups are incorporated into a consolidated risk characterisation.

Original languageEnglish
Article numbere05800
JournalEFSA Journal
Issue number9
Number of pages115
Publication statusPublished - 2019


  • acetylcholinesterase inhibition
  • cumulative assessment groups
  • cumulative risk assessment
  • motor division
  • nervous system
  • pesticides mixtures

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