Establishment of cumulative assessment groups of pesticides for their effects on the nervous system

European Food Safety Authority (EFSA)

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Cumulative assessment groups of pesticides have been established for five effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, functional alterations of the motor, sensory and autonomic divisions, and histological neuropathological changes in neural tissue. Sources of uncertainties resulting from the methodological approach and from the limitations in available data and scientific knowledge have been identified and considered. This report supports the publication of a scientific report on cumulative risk assessment to pesticides affecting the nervous system, in which all uncertainties identified for either the exposure assessment or the establishment of the cumulative assessment groups are incorporated into a consolidated risk characterisation.

Original languageEnglish
Article numbere05800
JournalEFSA Journal
Volume17
Issue number9
Number of pages115
ISSN1831-4732
DOIs
Publication statusPublished - 2019

Keywords

  • acetylcholinesterase inhibition
  • cumulative assessment groups
  • cumulative risk assessment
  • motor division
  • nervous system
  • pesticides mixtures

Cite this

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title = "Establishment of cumulative assessment groups of pesticides for their effects on the nervous system",
abstract = "Cumulative assessment groups of pesticides have been established for five effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, functional alterations of the motor, sensory and autonomic divisions, and histological neuropathological changes in neural tissue. Sources of uncertainties resulting from the methodological approach and from the limitations in available data and scientific knowledge have been identified and considered. This report supports the publication of a scientific report on cumulative risk assessment to pesticides affecting the nervous system, in which all uncertainties identified for either the exposure assessment or the establishment of the cumulative assessment groups are incorporated into a consolidated risk characterisation.",
keywords = "acetylcholinesterase inhibition, cumulative assessment groups, cumulative risk assessment, motor division, nervous system, pesticides mixtures",
author = "{European Food Safety Authority (EFSA)} and Federica Crivellente and Andy Hart and Hernandez-Jerez, {Antonio F.} and {Hougaard Bennekou}, Susanne and Ragnor Pedersen and Andrea Terron and Gerrit Wolterink and Luc Mohimont",
year = "2019",
doi = "10.2903/j.efsa.2019.5800",
language = "English",
volume = "17",
journal = "E F S A Journal",
issn = "1831-4732",
publisher = "European Food Safety Authority (E F S A)",
number = "9",

}

Establishment of cumulative assessment groups of pesticides for their effects on the nervous system. / European Food Safety Authority (EFSA).

In: EFSA Journal, Vol. 17, No. 9, e05800, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Establishment of cumulative assessment groups of pesticides for their effects on the nervous system

AU - European Food Safety Authority (EFSA)

AU - Crivellente, Federica

AU - Hart, Andy

AU - Hernandez-Jerez, Antonio F.

AU - Hougaard Bennekou, Susanne

AU - Pedersen, Ragnor

AU - Terron, Andrea

AU - Wolterink, Gerrit

AU - Mohimont, Luc

PY - 2019

Y1 - 2019

N2 - Cumulative assessment groups of pesticides have been established for five effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, functional alterations of the motor, sensory and autonomic divisions, and histological neuropathological changes in neural tissue. Sources of uncertainties resulting from the methodological approach and from the limitations in available data and scientific knowledge have been identified and considered. This report supports the publication of a scientific report on cumulative risk assessment to pesticides affecting the nervous system, in which all uncertainties identified for either the exposure assessment or the establishment of the cumulative assessment groups are incorporated into a consolidated risk characterisation.

AB - Cumulative assessment groups of pesticides have been established for five effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, functional alterations of the motor, sensory and autonomic divisions, and histological neuropathological changes in neural tissue. Sources of uncertainties resulting from the methodological approach and from the limitations in available data and scientific knowledge have been identified and considered. This report supports the publication of a scientific report on cumulative risk assessment to pesticides affecting the nervous system, in which all uncertainties identified for either the exposure assessment or the establishment of the cumulative assessment groups are incorporated into a consolidated risk characterisation.

KW - acetylcholinesterase inhibition

KW - cumulative assessment groups

KW - cumulative risk assessment

KW - motor division

KW - nervous system

KW - pesticides mixtures

U2 - 10.2903/j.efsa.2019.5800

DO - 10.2903/j.efsa.2019.5800

M3 - Journal article

VL - 17

JO - E F S A Journal

JF - E F S A Journal

SN - 1831-4732

IS - 9

M1 - e05800

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