Epitopic Profiling of Antibody Response against Neurotoxins from the Black Mamba (Dendroaspis polylepis)

Martin Closter Jespersen, Mikael Engmark, Andreas Hougaard Laustsen, Jose Marfa Gutierrez, Bruno Lomonte, Mikael Rørdam Andersen, Ole Lund

    Research output: Contribution to conferencePosterResearchpeer-review

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    Abstract

    The black mamba (Dendroaspis Polylepis) is among the most dangerous snakes in the world, with a venom dominated by three-finger toxins and dendrotoxins. Among the three-finger toxins, the α-neurotoxins (α-NT) are the most important, and these are conserved between snake species. Cross-reactivity between threefinger toxins is known to occur, and understanding this phenomenon in depth may help guide future design of antivenoms to obtain optimal specificity against medically important toxins from different snake species. Using a bioinformatic approach, we investigated the cross-reactivity be- tween three-finger toxins for a rabbit antiserum raised against short neuro- toxin 1 from D. polylepis (SN1-DP).
    Original languageEnglish
    Publication date2015
    Number of pages1
    Publication statusPublished - 2015
    EventSymposium for Biological and Life Science Students (SymBLS) 2015 - Cambridge, United Kingdom
    Duration: 6 Nov 20156 Nov 2015

    Conference

    ConferenceSymposium for Biological and Life Science Students (SymBLS) 2015
    Country/TerritoryUnited Kingdom
    CityCambridge
    Period06/11/201506/11/2015

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