Epitopic Profiling of Antibody Response against Neurotoxins from the Black Mamba (Dendroaspis polylepis)

Martin Closter Jespersen; Mikael Engmark; Andreas Hougaard Laustsen; Jose Marfa Gutierrez; Bruno Lomonte; Mikael Rørdam Andersen; Ole Lund

Epitopic Profiling of Antibody Response against Neurotoxins from the Black Mamba (Dendroaspis polylepis)

Martin Closter Jespersen, Mikael Engmark, Andreas Hougaard Laustsen, Jose Marfa Gutierrez, Bruno Lomonte, Mikael Rørdam Andersen, Ole Lund

Research output: Contribution to conference › Poster › Research › peer-review

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Abstract

The black mamba (Dendroaspis Polylepis) is among the most dangerous snakes in the world, with a venom dominated by three-finger toxins and dendrotoxins. Among the three-finger toxins, the α-neurotoxins (α-NT) are the most important, and these are conserved between snake species. Cross-reactivity between threefinger toxins is known to occur, and understanding this phenomenon in depth may help guide future design of antivenoms to obtain optimal specificity against medically important toxins from different snake species. Using a bioinformatic approach, we investigated the cross-reactivity be- tween three-finger toxins for a rabbit antiserum raised against short neuro- toxin 1 from D. polylepis (SN1-DP).

Original language	English
Publication date	2015
Number of pages	1
Publication status	Published - 2015
Event	Symposium for Biological and Life Science Students (SymBLS) 2015 - Cambridge, United Kingdom Duration: 6 Nov 2015 → 6 Nov 2015

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Conference	Symposium for Biological and Life Science Students (SymBLS) 2015
Country/Territory	United Kingdom
City	Cambridge
Period	06/11/2015 → 06/11/2015

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Epitopic Profiling of Antibody Response against Neurotoxins from the Black Mamba Dendroaspis polylepis Final published version, 9.27 MB

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title = "Epitopic Profiling of Antibody Response against Neurotoxins from the Black Mamba (Dendroaspis polylepis)",

abstract = "The black mamba (Dendroaspis Polylepis) is among the most dangerous snakes in the world, with a venom dominated by three-finger toxins and dendrotoxins. Among the three-finger toxins, the α-neurotoxins (α-NT) are the most important, and these are conserved between snake species. Cross-reactivity between threefinger toxins is known to occur, and understanding this phenomenon in depth may help guide future design of antivenoms to obtain optimal specificity against medically important toxins from different snake species. Using a bioinformatic approach, we investigated the cross-reactivity be- tween three-finger toxins for a rabbit antiserum raised against short neuro- toxin 1 from D. polylepis (SN1-DP).",

author = "Jespersen, {Martin Closter} and Mikael Engmark and Laustsen, {Andreas Hougaard} and {Marfa Gutierrez}, Jose and Bruno Lomonte and Andersen, {Mikael R{\o}rdam} and Ole Lund",

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Epitopic Profiling of Antibody Response against Neurotoxins from the Black Mamba (Dendroaspis polylepis). / Jespersen, Martin Closter; Engmark, Mikael; Laustsen, Andreas Hougaard et al.
2015. Poster session presented at Symposium for Biological and Life Science Students (SymBLS) 2015, Cambridge, United Kingdom.

Research output: Contribution to conference › Poster › Research › peer-review

TY - CONF

T1 - Epitopic Profiling of Antibody Response against Neurotoxins from the Black Mamba (Dendroaspis polylepis)

AU - Jespersen, Martin Closter

AU - Engmark, Mikael

AU - Laustsen, Andreas Hougaard

AU - Marfa Gutierrez, Jose

AU - Lomonte, Bruno

AU - Andersen, Mikael Rørdam

AU - Lund, Ole

PY - 2015

Y1 - 2015

N2 - The black mamba (Dendroaspis Polylepis) is among the most dangerous snakes in the world, with a venom dominated by three-finger toxins and dendrotoxins. Among the three-finger toxins, the α-neurotoxins (α-NT) are the most important, and these are conserved between snake species. Cross-reactivity between threefinger toxins is known to occur, and understanding this phenomenon in depth may help guide future design of antivenoms to obtain optimal specificity against medically important toxins from different snake species. Using a bioinformatic approach, we investigated the cross-reactivity be- tween three-finger toxins for a rabbit antiserum raised against short neuro- toxin 1 from D. polylepis (SN1-DP).

AB - The black mamba (Dendroaspis Polylepis) is among the most dangerous snakes in the world, with a venom dominated by three-finger toxins and dendrotoxins. Among the three-finger toxins, the α-neurotoxins (α-NT) are the most important, and these are conserved between snake species. Cross-reactivity between threefinger toxins is known to occur, and understanding this phenomenon in depth may help guide future design of antivenoms to obtain optimal specificity against medically important toxins from different snake species. Using a bioinformatic approach, we investigated the cross-reactivity be- tween three-finger toxins for a rabbit antiserum raised against short neuro- toxin 1 from D. polylepis (SN1-DP).

M3 - Poster

T2 - Symposium for Biological and Life Science Students (SymBLS) 2015

Y2 - 6 November 2015 through 6 November 2015

ER -

Epitopic Profiling of Antibody Response against Neurotoxins from the Black Mamba (Dendroaspis polylepis)

Abstract

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