Epistatic Mutations And Unpredictable Phenotypes In Pseudomonas Aeruginosa

Eva Kammer Andresen, Maher Abou Hachem, Lars Jelsbak

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

    Abstract

    Pseudomonas aeruginosa is an opportunistic pathogen, able to adapt to stressful environments such as the cystic fibrosis (CF) airways. Adaptation of P. aeruginosa to the CF environment is associated with phenotypic changes, such as switch in mucoidy, antibiotic resistance and loss of virulence factors. The phenotypic changes arise from mutations in trans-regulatory elements but are nearly impossible to predict from sequence data alone. Often, the combinatorial effects of few mutations in global regulators give rise to unexpected phenotypes. To understand the epistatic effect and how unexpected phenotypes arise from seemingly unrelated mutations, we have studied two mutations in P. aeruginosa transcriptional regulators, sigma factor rpoD and algT.
    Original languageEnglish
    Title of host publicationThe Danish Microbiological Society Annual Congress 2015 : Programme & Abstracts
    Place of PublicationCopenhagen
    Publication date2015
    Pages49-49
    Publication statusPublished - 2015
    EventThe Danish Microbiological Society Annual Congress 2015 - Eigtved's Pakhus, Copenhagen, Denmark
    Duration: 9 Nov 20159 Nov 2015

    Conference

    ConferenceThe Danish Microbiological Society Annual Congress 2015
    LocationEigtved's Pakhus
    CountryDenmark
    CityCopenhagen
    Period09/11/201509/11/2015

    Cite this

    Andresen, E. K., Abou Hachem, M., & Jelsbak, L. (2015). Epistatic Mutations And Unpredictable Phenotypes In Pseudomonas Aeruginosa. In The Danish Microbiological Society Annual Congress 2015: Programme & Abstracts (pp. 49-49). Copenhagen.
    Andresen, Eva Kammer ; Abou Hachem, Maher ; Jelsbak, Lars. / Epistatic Mutations And Unpredictable Phenotypes In Pseudomonas Aeruginosa. The Danish Microbiological Society Annual Congress 2015: Programme & Abstracts. Copenhagen, 2015. pp. 49-49
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    abstract = "Pseudomonas aeruginosa is an opportunistic pathogen, able to adapt to stressful environments such as the cystic fibrosis (CF) airways. Adaptation of P. aeruginosa to the CF environment is associated with phenotypic changes, such as switch in mucoidy, antibiotic resistance and loss of virulence factors. The phenotypic changes arise from mutations in trans-regulatory elements but are nearly impossible to predict from sequence data alone. Often, the combinatorial effects of few mutations in global regulators give rise to unexpected phenotypes. To understand the epistatic effect and how unexpected phenotypes arise from seemingly unrelated mutations, we have studied two mutations in P. aeruginosa transcriptional regulators, sigma factor rpoD and algT.",
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    Andresen, EK, Abou Hachem, M & Jelsbak, L 2015, Epistatic Mutations And Unpredictable Phenotypes In Pseudomonas Aeruginosa. in The Danish Microbiological Society Annual Congress 2015: Programme & Abstracts. Copenhagen, pp. 49-49, The Danish Microbiological Society Annual Congress 2015, Copenhagen, Denmark, 09/11/2015.

    Epistatic Mutations And Unpredictable Phenotypes In Pseudomonas Aeruginosa. / Andresen, Eva Kammer; Abou Hachem, Maher ; Jelsbak, Lars.

    The Danish Microbiological Society Annual Congress 2015: Programme & Abstracts. Copenhagen, 2015. p. 49-49.

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

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    N2 - Pseudomonas aeruginosa is an opportunistic pathogen, able to adapt to stressful environments such as the cystic fibrosis (CF) airways. Adaptation of P. aeruginosa to the CF environment is associated with phenotypic changes, such as switch in mucoidy, antibiotic resistance and loss of virulence factors. The phenotypic changes arise from mutations in trans-regulatory elements but are nearly impossible to predict from sequence data alone. Often, the combinatorial effects of few mutations in global regulators give rise to unexpected phenotypes. To understand the epistatic effect and how unexpected phenotypes arise from seemingly unrelated mutations, we have studied two mutations in P. aeruginosa transcriptional regulators, sigma factor rpoD and algT.

    AB - Pseudomonas aeruginosa is an opportunistic pathogen, able to adapt to stressful environments such as the cystic fibrosis (CF) airways. Adaptation of P. aeruginosa to the CF environment is associated with phenotypic changes, such as switch in mucoidy, antibiotic resistance and loss of virulence factors. The phenotypic changes arise from mutations in trans-regulatory elements but are nearly impossible to predict from sequence data alone. Often, the combinatorial effects of few mutations in global regulators give rise to unexpected phenotypes. To understand the epistatic effect and how unexpected phenotypes arise from seemingly unrelated mutations, we have studied two mutations in P. aeruginosa transcriptional regulators, sigma factor rpoD and algT.

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    Andresen EK, Abou Hachem M, Jelsbak L. Epistatic Mutations And Unpredictable Phenotypes In Pseudomonas Aeruginosa. In The Danish Microbiological Society Annual Congress 2015: Programme & Abstracts. Copenhagen. 2015. p. 49-49