Pseudomonas aeruginosa is an opportunistic pathogen, able to adapt to stressful environments such as the cystic fibrosis (CF) airways. Adaptation of P. aeruginosa to the CF environment is associated with phenotypic changes, such as switch in mucoidy, antibiotic resistance and loss of virulence factors. The phenotypic changes arise from mutations in trans-regulatory elements but are nearly impossible to predict from sequence data alone. Often, the combinatorial effects of few mutations in global regulators give rise to unexpected phenotypes. To understand the epistatic effect and how unexpected phenotypes arise from seemingly unrelated mutations, we have studied two mutations in P. aeruginosa transcriptional regulators, sigma factor rpoD and algT.
|Title of host publication||The Danish Microbiological Society Annual Congress 2015 : Programme & Abstracts|
|Place of Publication||Copenhagen|
|Publication status||Published - 2015|
|Event||The Danish Microbiological Society Annual Congress 2015 - Eigtved's Pakhus, Copenhagen, Denmark|
Duration: 9 Nov 2015 → 9 Nov 2015
|Conference||The Danish Microbiological Society Annual Congress 2015|
|Period||09/11/2015 → 09/11/2015|
Andresen, E. K., Abou Hachem, M., & Jelsbak, L. (2015). Epistatic Mutations And Unpredictable Phenotypes In Pseudomonas Aeruginosa. In The Danish Microbiological Society Annual Congress 2015: Programme & Abstracts (pp. 49-49). Copenhagen.