TY - JOUR
T1 - epi-Aszonalenins A, B, and C from Aspergillus novofumigatus
AU - Rank, Christian
AU - Phipps, Richard Kerry
AU - Harris, Pernille
AU - Frisvad, Jens Christian
AU - Gotfredsen, Charlotte Held
AU - Larsen, Thomas Ostenfeld
PY - 2006
Y1 - 2006
N2 - Three new benzodiazepines have been isolated from an unusual chemotype of Aspergillus novofumigatus: epi-aszonalenins A, B, and C. The structures were elucidated by use of one- and two-dimensional NMR spectroscopic techniques and HR ESI MS. The relative configuration was established on the basis of a single crystal X-ray diffraction study of epi-aszonalenin A and the absolute configuration was determined by optical rotation comparison with the literature data. The absolute configurations of epi-aszonalenins B and C were determined by circular dichroism comparison to epi-aszonalenin A.
AB - Three new benzodiazepines have been isolated from an unusual chemotype of Aspergillus novofumigatus: epi-aszonalenins A, B, and C. The structures were elucidated by use of one- and two-dimensional NMR spectroscopic techniques and HR ESI MS. The relative configuration was established on the basis of a single crystal X-ray diffraction study of epi-aszonalenin A and the absolute configuration was determined by optical rotation comparison with the literature data. The absolute configurations of epi-aszonalenins B and C were determined by circular dichroism comparison to epi-aszonalenin A.
U2 - 10.1016/j.tetlet.2006.06.086
DO - 10.1016/j.tetlet.2006.06.086
M3 - Journal article
SN - 0040-4039
VL - 47
SP - 6099
EP - 6102
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 34
ER -