epi-Aszonalenins A, B, and C from Aspergillus novofumigatus

Christian Rank, Richard Kerry Phipps, Pernille Harris, Jens Christian Frisvad, Charlotte Held Gotfredsen, Thomas Ostenfeld Larsen

Research output: Contribution to journalJournal articleResearchpeer-review


Three new benzodiazepines have been isolated from an unusual chemotype of Aspergillus novofumigatus: epi-aszonalenins A, B, and C. The structures were elucidated by use of one- and two-dimensional NMR spectroscopic techniques and HR ESI MS. The relative configuration was established on the basis of a single crystal X-ray diffraction study of epi-aszonalenin A and the absolute configuration was determined by optical rotation comparison with the literature data. The absolute configurations of epi-aszonalenins B and C were determined by circular dichroism comparison to epi-aszonalenin A.
Original languageEnglish
JournalTetrahedron Letters
Issue number34
Pages (from-to)6099-6102
Publication statusPublished - 2006


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