Eosinophils are key regulators of perivascular adipose tissue and vascular functionality

Sarah B. Withers, Ruth Forman, Selene Meza-Perez, Daniel Sorobetea, Kasia Sitnik, Thomas Hopwood, Catherine B. Lawrence, William Winston Agace, Kathryn J. Else, Anthony M. Heagerty, Marcus Svensson Frej, Sheena M. Cruickshank*

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    Abstract

    Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension and impaired glucose intolerance. Resident immune cells are thought to regulate adipocyte activity. We investigated the role of eosinophils in mediating normal PVAT function. Healthy PVAT elicits an anti-contractile effect, which was lost in mice deficient in eosinophils, mimicking the obese phenotype, and was restored upon eosinophil reconstitution. Ex vivo studies demonstrated that the loss of PVAT function was due to reduced bioavailability of adiponectin and adipocyte-derived nitric oxide, which was restored after eosinophil reconstitution. Mechanistic studies demonstrated that adiponectin and nitric oxide are released after activation of adipocyte-expressed β3 adrenoceptors by catecholamines, and identified eosinophils as a novel source of these mediators. We conclude that adipose tissue eosinophils play a key role in the regulation of normal PVAT anti-contractile function.

    Original languageEnglish
    Article number44571
    JournalScientific Reports
    Volume7
    Number of pages12
    ISSN2045-2322
    DOIs
    Publication statusPublished - 2017

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