Abstract
Rapid progress in biochemistry of phospholipids and evolution of modern bioengineering has
brought forth a number of novel concepts and technical advancements in the modification of
phospholipids for industrial applications and human nutrition. Highlights cover preparation of novel
phospholipid analogs based on the latest understanding of pivotal role of phospholipids in manifold
biological processes, exploration of remarkable application potentials of phospholipids in
meliorating human health, as well as development of new chemical and biotechnological approaches
applied to the modification of phospholipids. This work reviews the natural occurrence and structural
characteristics of phospholipids, their updated knowledge on manifold biological and nutritional
functions, traditional and novel physical and chemical approaches to modify phospholipids as well as
their applications to obtain novel phospholipids, and brief introduction of the efforts focusing on de
novo syntheses of phospholipids. Special attention is given to the summary of molecular structural
characteristics and catalytic properties of multiple phospholipases, which helps to interpret
experimental phenomena and to improve reaction design. This will of course provide fundamental
bases also for the development of enzymatic technology to produce structured or modified
phospholipids.
Original language | English |
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Journal | Biotechnology Advances |
Volume | 23 |
Pages (from-to) | 203-259 |
ISSN | 0734-9750 |
Publication status | Published - 2005 |