Enzymatic Biofuel Cells for Self-Powered, Controlled Drug Release

Xinxin Xiao*, Kieran Denis McGourty, Edmond Magner

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Self-powered drug-delivery systems based on conductive polymers (CPs) that eliminate the need for external power sources are of significant interest for use in clinical applications. Osmium redox polymer-mediated glucose/O2 enzymatic biofuel cells (EBFCs) were prepared with an additional CP-drug layer on the cathode. On discharging the EBFCs in the presence of glucose and dioxygen, model drug compounds incorporated in the CP layer were rapidly released with negligible amounts released when the EBFCs were held at open circuit. Controlled and ex situ release of three model compounds, ibuprofen (IBU), fluorescein (FLU), and 4',6-diamidino-2-phenylindole (DAPI), was achieved with this self-powered drug-release system. DAPI released in situ in cell culture media was incorporated into retinal pigment epithelium (RPE) cells. This work demonstrates a proof-of-concept responsive drug-release system that may be used in implantable devices.

Original languageEnglish
JournalJournal of the American Chemical Society
Volume142
Issue number26
Pages (from-to)11602–11609
ISSN0002-7863
DOIs
Publication statusPublished - 2020

Fingerprint Dive into the research topics of 'Enzymatic Biofuel Cells for Self-Powered, Controlled Drug Release'. Together they form a unique fingerprint.

Cite this