Enterotypes influence temporal changes in gut microbiota

Henrik Munch Roager, Tine Rask Licht, Sanne Kellebjerg Poulsen, Thomas Meinert Larsen, Martin Iain Bahl

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The human gut microbiota plays an important role for human health. The question is whether we can modulate the gut microbiota by changing diet. During a 6-month, randomised, controlled dietary intervention, the effect of consuming a diet following the New Nordic Diet recommendations (NND) as opposed to Average Danish Diet (ADD) on the gut microbiota in humans (n=62) was investigated. Quantitative PCR analysis showed that the microbiota did not change significantly by the intervention. Nevertheless, by stratifying subjects into two enterotypes, distinguished by the Prevotella/Bacteroides ratio (P/B), we were able to detect significant changes in the gut microbiota composition resulting from the interventions. Subjects with a high-P/B experienced more pronounced changes in the gut microbiota composition than subjects with a low-P/B. The study is the first to indicate that enterotypes influence microbiota response to a dietary intervention. The distinguishment of enterotypes by P/B could be a simple approach to assess the effect of diets and other treatments on the gut microbiota.
Original languageEnglish
Publication date2013
Number of pages1
Publication statusPublished - 2013
Event8th Danish Conference on Biotechnology and Molecular Biology: Food Biotechnology and Nutigenomics - Vejle, Denmark
Duration: 30 May 201331 May 2013
Conference number: 8


Conference8th Danish Conference on Biotechnology and Molecular Biology
Internet address


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