The human gut microbiota plays an important role for human health. The question is whether we can modulate the gut microbiota by changing diet. During a 6-month, randomised, controlled dietary intervention, the effect of consuming a diet following the New Nordic Diet recommendations (NND) as opposed to Average Danish Diet (ADD) on the gut microbiota in humans (n=62) was investigated. Quantitative PCR analysis showed that the microbiota did not change significantly by the intervention. Nevertheless, by stratifying subjects into two enterotypes, distinguished by the Prevotella/Bacteroides ratio (P/B), we were able to detect significant changes in the gut microbiota composition resulting from the interventions. Subjects with a high-P/B experienced more pronounced changes in the gut microbiota composition than subjects with a low-P/B. The study is the first to indicate that enterotypes influence microbiota response to a dietary intervention. The distinguishment of enterotypes by P/B could be a simple approach to assess the effect of diets and other treatments on the gut microbiota.
|Number of pages||1|
|Publication status||Published - 2013|
|Event||8th Danish Conference on Biotechnology and Molecular Biology: Food Biotechnology and Nutigenomics - Vejle, Denmark|
Duration: 30 May 2013 → 31 May 2013
Conference number: 8
|Conference||8th Danish Conference on Biotechnology and Molecular Biology|
|Period||30/05/2013 → 31/05/2013|