Enterotypes influence temporal changes in gut microbiota

Henrik Munch Roager, Tine Rask Licht, Sanne Kellebjerg Poulsen, Thomas Meinert Larsen, Martin Iain Bahl

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The human gut microbiota plays an important role for the health of the host. The question is whether we can modulate the gut microbiota by changing diet. During a 6-month, randomised, controlled dietary intervention, the effect of a moderate diet shift from Average Danish Diet to New Nordic Diet on the gut microbiota in humans (n=62) was investigated. Quantitative PCR analysis showed that the microbiota did not change significantly by the intervention.
Nevertheless, by stratifying subjects into two enterotypes, distinguished by the Prevotella/Bacteroides ratio (P/B), we were able to detect significant changes in the gut microbiota composition resulting from the interventions. Subjects with a high-P/B experienced more pronounced changes in the gut microbiota composition than subjects with a low-P/B. The study is the first to indicate that enterotypes influence microbiota response to a dietary intervention.
Original languageEnglish
Publication date2013
Number of pages1
Publication statusPublished - 2013
EventCell Symposia: Microbiome and Host Health - Lisbon, Portugal
Duration: 12 May 201314 May 2013


ConferenceCell Symposia
Internet address


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