Enhanced 13C NMR detects extended reaction networks in living cells

Pernille Rose Jensen; Francesca Sannelli; Ludvig Tving Stauning; Sebastian Meier

doi:10.1039/d1cc03838a

Enhanced ¹³C NMR detects extended reaction networks in living cells

Pernille Rose Jensen^*
, Francesca Sannelli
, Ludvig Tving Stauning
, Sebastian Meier^*

^*Corresponding author for this work

Technical University of Denmark

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Insights into intracellular chemistry have remained sparse, but would be impactful for the advancement of biomedicine and bioproduction. A suitable ¹³C NMR approach provides improvements in sensitivity that make extended reaction networks and assay time windows, previously inaccessible cell densities and relative flux measurements accessible in living cells.

Original language	English
Journal	Chemical Communications
Volume	57
Issue number	81
Pages (from-to)	10572-10575
Number of pages	4
ISSN	1359-7345
DOIs	https://doi.org/10.1039/d1cc03838a
Publication status	Published - 2021

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title = "Enhanced 13C NMR detects extended reaction networks in living cells",

abstract = "Insights into intracellular chemistry have remained sparse, but would be impactful for the advancement of biomedicine and bioproduction. A suitable 13C NMR approach provides improvements in sensitivity that make extended reaction networks and assay time windows, previously inaccessible cell densities and relative flux measurements accessible in living cells.",

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AU - Sannelli, Francesca

AU - Stauning, Ludvig Tving

AU - Meier, Sebastian

PY - 2021

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N2 - Insights into intracellular chemistry have remained sparse, but would be impactful for the advancement of biomedicine and bioproduction. A suitable 13C NMR approach provides improvements in sensitivity that make extended reaction networks and assay time windows, previously inaccessible cell densities and relative flux measurements accessible in living cells.

AB - Insights into intracellular chemistry have remained sparse, but would be impactful for the advancement of biomedicine and bioproduction. A suitable 13C NMR approach provides improvements in sensitivity that make extended reaction networks and assay time windows, previously inaccessible cell densities and relative flux measurements accessible in living cells.

U2 - 10.1039/d1cc03838a

DO - 10.1039/d1cc03838a

M3 - Journal article

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SN - 1359-7345

VL - 57

SP - 10572

EP - 10575

JO - Chemical Communications

JF - Chemical Communications

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