Enhanced reactivity of dinuclear Copper(I) acetylides in dipolar cycloadditions

Mårten Sten Gösta Ahlquist; V.V. Fokin

doi:10.1021/om700669v

Enhanced reactivity of dinuclear Copper(I) acetylides in dipolar cycloadditions

Mårten Sten Gösta Ahlquist, V.V. Fokin

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Dinuclear alkynyl copper(I) complexes exhibit superior reactivity toward organic azides compared to their monomeric analogues. DFT studies indicate that the second copper center facilitates the formation of the cupracycle in the rate-determining step and stabilizes the metallacycle intermediate itself. These findings support the experimentally determined rate law and shed light on the origin of high reactivity of the in situ generated copper acetylides.

Original language	English
Journal	Organometallics
Volume	26
Issue number	18
Pages (from-to)	4389-4391
ISSN	0276-7333
DOIs	https://doi.org/10.1021/om700669v
Publication status	Published - 2007

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title = "Enhanced reactivity of dinuclear Copper(I) acetylides in dipolar cycloadditions",

abstract = "Dinuclear alkynyl copper(I) complexes exhibit superior reactivity toward organic azides compared to their monomeric analogues. DFT studies indicate that the second copper center facilitates the formation of the cupracycle in the rate-determining step and stabilizes the metallacycle intermediate itself. These findings support the experimentally determined rate law and shed light on the origin of high reactivity of the in situ generated copper acetylides.",

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T1 - Enhanced reactivity of dinuclear Copper(I) acetylides in dipolar cycloadditions

AU - Ahlquist, Mårten Sten Gösta

AU - Fokin, V.V.

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Y1 - 2007

N2 - Dinuclear alkynyl copper(I) complexes exhibit superior reactivity toward organic azides compared to their monomeric analogues. DFT studies indicate that the second copper center facilitates the formation of the cupracycle in the rate-determining step and stabilizes the metallacycle intermediate itself. These findings support the experimentally determined rate law and shed light on the origin of high reactivity of the in situ generated copper acetylides.

AB - Dinuclear alkynyl copper(I) complexes exhibit superior reactivity toward organic azides compared to their monomeric analogues. DFT studies indicate that the second copper center facilitates the formation of the cupracycle in the rate-determining step and stabilizes the metallacycle intermediate itself. These findings support the experimentally determined rate law and shed light on the origin of high reactivity of the in situ generated copper acetylides.

U2 - 10.1021/om700669v

DO - 10.1021/om700669v

M3 - Journal article

SN - 0276-7333

VL - 26

SP - 4389

EP - 4391

JO - Organometallics

JF - Organometallics

IS - 18

ER -

Enhanced reactivity of dinuclear Copper(I) acetylides in dipolar cycloadditions

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