Enhanced Plasmon-Induced Resonance Energy Transfer (PIRET)-mediated Photothermal and Photodynamic Therapy Guided by Photoacoustic and Magnetic Resonance Imaging

Tao Zheng, Tongchang Zhou, Xiaotong Feng, Jian Shen, Ming Zhang, Yi Sun

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Phototherapy, containing photothermal and photodynamic therapy, has attracted extensive attention due to its noninvasive nature, low toxicity, and high anticancer efficiency. Charge-separation mechanism of plasmon-induced resonance energy transfer (PIRET), has been increasingly employed to design nanotheranotic agents. Herein, we developed a novel and smart PIRET-mediated nanoplatform for enhanced, imaging-guided phototherapy. Prussian blue (PB) was incorporated into Au@Cu2O nanostructure, which was then assembled with poly(allylamine) (PAH) modified black phosphorus quantum dots (Au@PB@Cu2O@BPQDs/PAH nanocomposites). The hybrid nanosystem exhibited great absorption in NIR region, as well as the ability to self-supply O2 by catalyzing hydrogen peroxide and convert O2 into singlet oxygen (1O2) under 650 nm laser light (0.5 W/cm2) irradiation. In vitro and in vivo assay showed that the generated heat and toxic 1O2 from Au@PB@Cu2O@BPQDs/PAH nanocomposites could effectively kill the cancer cells and suppress tumor growth. Moreover, the unique properties of PB modified nanosystem allowed for synergistic therapy with the aid of T1-weighed magnetic resonance imaging (T1-weighted MRI) and photoacoustic imaging (PAI). This study presented a suitable way to fabricate smart PIRET-based nanosystem with enhanced PTT/PDT efficacy and dual-modal imaging functionality. The great biocompatibility and low toxicity ensured their high potential for use in cancer therapy
Original languageEnglish
JournalA C S Applied Materials and Interfaces
Volume11
Issue number35
Pages (from-to)31615-31626
ISSN1944-8244
DOIs
Publication statusPublished - 2019

Keywords

  • Phototherapy
  • Plasmon-induced resonance energy transfer
  • Prussian blue
  • Magnetic resonance imaging
  • Photoacoustic imaging
  • Biocompatibility

Cite this

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title = "Enhanced Plasmon-Induced Resonance Energy Transfer (PIRET)-mediated Photothermal and Photodynamic Therapy Guided by Photoacoustic and Magnetic Resonance Imaging",
abstract = "Phototherapy, containing photothermal and photodynamic therapy, has attracted extensive attention due to its noninvasive nature, low toxicity, and high anticancer efficiency. Charge-separation mechanism of plasmon-induced resonance energy transfer (PIRET), has been increasingly employed to design nanotheranotic agents. Herein, we developed a novel and smart PIRET-mediated nanoplatform for enhanced, imaging-guided phototherapy. Prussian blue (PB) was incorporated into Au@Cu2O nanostructure, which was then assembled with poly(allylamine) (PAH) modified black phosphorus quantum dots (Au@PB@Cu2O@BPQDs/PAH nanocomposites). The hybrid nanosystem exhibited great absorption in NIR region, as well as the ability to self-supply O2 by catalyzing hydrogen peroxide and convert O2 into singlet oxygen (1O2) under 650 nm laser light (0.5 W/cm2) irradiation. In vitro and in vivo assay showed that the generated heat and toxic 1O2 from Au@PB@Cu2O@BPQDs/PAH nanocomposites could effectively kill the cancer cells and suppress tumor growth. Moreover, the unique properties of PB modified nanosystem allowed for synergistic therapy with the aid of T1-weighed magnetic resonance imaging (T1-weighted MRI) and photoacoustic imaging (PAI). This study presented a suitable way to fabricate smart PIRET-based nanosystem with enhanced PTT/PDT efficacy and dual-modal imaging functionality. The great biocompatibility and low toxicity ensured their high potential for use in cancer therapy",
keywords = "Phototherapy, Plasmon-induced resonance energy transfer, Prussian blue, Magnetic resonance imaging, Photoacoustic imaging, Biocompatibility",
author = "Tao Zheng and Tongchang Zhou and Xiaotong Feng and Jian Shen and Ming Zhang and Yi Sun",
year = "2019",
doi = "10.1021/acsami.9b09296",
language = "English",
volume = "11",
pages = "31615--31626",
journal = "A C S Applied Materials and Interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "35",

}

Enhanced Plasmon-Induced Resonance Energy Transfer (PIRET)-mediated Photothermal and Photodynamic Therapy Guided by Photoacoustic and Magnetic Resonance Imaging. / Zheng, Tao; Zhou, Tongchang; Feng, Xiaotong; Shen, Jian ; Zhang, Ming; Sun, Yi.

In: A C S Applied Materials and Interfaces, Vol. 11, No. 35, 2019, p. 31615-31626.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Enhanced Plasmon-Induced Resonance Energy Transfer (PIRET)-mediated Photothermal and Photodynamic Therapy Guided by Photoacoustic and Magnetic Resonance Imaging

AU - Zheng, Tao

AU - Zhou, Tongchang

AU - Feng, Xiaotong

AU - Shen, Jian

AU - Zhang, Ming

AU - Sun, Yi

PY - 2019

Y1 - 2019

N2 - Phototherapy, containing photothermal and photodynamic therapy, has attracted extensive attention due to its noninvasive nature, low toxicity, and high anticancer efficiency. Charge-separation mechanism of plasmon-induced resonance energy transfer (PIRET), has been increasingly employed to design nanotheranotic agents. Herein, we developed a novel and smart PIRET-mediated nanoplatform for enhanced, imaging-guided phototherapy. Prussian blue (PB) was incorporated into Au@Cu2O nanostructure, which was then assembled with poly(allylamine) (PAH) modified black phosphorus quantum dots (Au@PB@Cu2O@BPQDs/PAH nanocomposites). The hybrid nanosystem exhibited great absorption in NIR region, as well as the ability to self-supply O2 by catalyzing hydrogen peroxide and convert O2 into singlet oxygen (1O2) under 650 nm laser light (0.5 W/cm2) irradiation. In vitro and in vivo assay showed that the generated heat and toxic 1O2 from Au@PB@Cu2O@BPQDs/PAH nanocomposites could effectively kill the cancer cells and suppress tumor growth. Moreover, the unique properties of PB modified nanosystem allowed for synergistic therapy with the aid of T1-weighed magnetic resonance imaging (T1-weighted MRI) and photoacoustic imaging (PAI). This study presented a suitable way to fabricate smart PIRET-based nanosystem with enhanced PTT/PDT efficacy and dual-modal imaging functionality. The great biocompatibility and low toxicity ensured their high potential for use in cancer therapy

AB - Phototherapy, containing photothermal and photodynamic therapy, has attracted extensive attention due to its noninvasive nature, low toxicity, and high anticancer efficiency. Charge-separation mechanism of plasmon-induced resonance energy transfer (PIRET), has been increasingly employed to design nanotheranotic agents. Herein, we developed a novel and smart PIRET-mediated nanoplatform for enhanced, imaging-guided phototherapy. Prussian blue (PB) was incorporated into Au@Cu2O nanostructure, which was then assembled with poly(allylamine) (PAH) modified black phosphorus quantum dots (Au@PB@Cu2O@BPQDs/PAH nanocomposites). The hybrid nanosystem exhibited great absorption in NIR region, as well as the ability to self-supply O2 by catalyzing hydrogen peroxide and convert O2 into singlet oxygen (1O2) under 650 nm laser light (0.5 W/cm2) irradiation. In vitro and in vivo assay showed that the generated heat and toxic 1O2 from Au@PB@Cu2O@BPQDs/PAH nanocomposites could effectively kill the cancer cells and suppress tumor growth. Moreover, the unique properties of PB modified nanosystem allowed for synergistic therapy with the aid of T1-weighed magnetic resonance imaging (T1-weighted MRI) and photoacoustic imaging (PAI). This study presented a suitable way to fabricate smart PIRET-based nanosystem with enhanced PTT/PDT efficacy and dual-modal imaging functionality. The great biocompatibility and low toxicity ensured their high potential for use in cancer therapy

KW - Phototherapy

KW - Plasmon-induced resonance energy transfer

KW - Prussian blue

KW - Magnetic resonance imaging

KW - Photoacoustic imaging

KW - Biocompatibility

U2 - 10.1021/acsami.9b09296

DO - 10.1021/acsami.9b09296

M3 - Journal article

VL - 11

SP - 31615

EP - 31626

JO - A C S Applied Materials and Interfaces

JF - A C S Applied Materials and Interfaces

SN - 1944-8244

IS - 35

ER -