Enhanced performance large volume dissolution-DNP

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A systematic study of the performance of the dissolution process in dissolution-DNP is presented. A relatively simple set of modifications is made to the standard Hypersense dissolution system to enable polarization of large volume samples. These consist of a large volume sample cup along with supporting modifications to the dissolution head and related components. Additional modifications were made to support the mapping of the temperature/pressure space of the dissolution process as well as enabling the use of large volumes of solvent and improving the robustness of the system. No loss of polarization was observed as sample size was increased to the 1g capacity of the large volume cup and for a dilution factor as low as 1:10.
Original languageEnglish
JournalJournal of Magnetic Resonance
Volume240
Pages (from-to)90-94
ISSN1090-7807
DOIs
Publication statusPublished - 2014

Keywords

  • NMR
  • Hyperpolarization
  • Dynamic nuclear polarization

Cite this