We present the efficient and stable encapsulation of doxorubicin within pH sensitive polymeric vesicles (polymersomes) for intracellular and nuclear delivery to melanoma cells. We demonstrate that PMPC25-PDPA70 polymersomes can encapsulate doxorubicin for long periods of time without significant drug release. We demonstrate that empty polymersomes are non-toxic and that they are quickly and more efficiently internalised by melanoma cells compared to healthy cells. Encapsulated doxorubicin has a strong cytotoxic effect on both healthy and cancerous cells, but when encapsulated it had a preferential effect on melanoma cells indicating that this formulation can be used to achieve an enhanced drug delivery to cancerous cells rather than to the healthy surrounding cells.
- Targeted delivery
Pegoraro, C., Cecchin, D., Gracia, L. S., Warren, N. J., Jeppe Madsen, P., Armes, S. P., Lewis, A., MacNeil, S., & Battaglia, G. (2013). Enhanced drug delivery to melanoma cells using PMPC-PDPA polymersomes. Cancer Letters, 334(2), 328-337. https://doi.org/10.1016/j.canlet.2013.02.007