Enhanced drug delivery to melanoma cells using PMPC-PDPA polymersomes

Carla Pegoraro, Denis Cecchin, Lorena Simon Gracia, Nicholas J. Warren, Peter Jeppe Madsen, Steven P. Armes, Andrew Lewis, Sheila MacNeil, Giuseppe Battaglia

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We present the efficient and stable encapsulation of doxorubicin within pH sensitive polymeric vesicles (polymersomes) for intracellular and nuclear delivery to melanoma cells. We demonstrate that PMPC25-PDPA70 polymersomes can encapsulate doxorubicin for long periods of time without significant drug release. We demonstrate that empty polymersomes are non-toxic and that they are quickly and more efficiently internalised by melanoma cells compared to healthy cells. Encapsulated doxorubicin has a strong cytotoxic effect on both healthy and cancerous cells, but when encapsulated it had a preferential effect on melanoma cells indicating that this formulation can be used to achieve an enhanced drug delivery to cancerous cells rather than to the healthy surrounding cells.
Original languageEnglish
JournalCancer Letters
Volume334
Issue number2
Pages (from-to)328-337
Number of pages10
ISSN0304-3835
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Polymersomes
  • Melanoma
  • Targeted delivery
  • Doxorubicin

Cite this

Pegoraro, C., Cecchin, D., Gracia, L. S., Warren, N. J., Jeppe Madsen, P., Armes, S. P., Lewis, A., MacNeil, S., & Battaglia, G. (2013). Enhanced drug delivery to melanoma cells using PMPC-PDPA polymersomes. Cancer Letters, 334(2), 328-337. https://doi.org/10.1016/j.canlet.2013.02.007