Enhanced Depth Imaging OCT and OCT Angiography for Quantifying Optic Disc Drusen and Related Complications

Anne-Sofie Wessel Lindberg

Research output: Book/ReportPh.D. thesis

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Enhanced Depth Imaging Optical Coherence Tomography (EDI-OCT) is a modification of Spectral Domain Optical Coherence Tomography (SD-OCT). EDI-OCT enables imaging of deep located structures more clearly than standard SD-OCT. In this thesis, we investigate the use of EDI-OCT for 3D quantification of spherical calcified objects in the optic nerve head known as the disease Optic Disc Drusen (ODD). With the use of image analysis, we quantify the ODD volume and anatomical location. Next, we investigate how to optimize the visual appearance of anatomical structures such as ODD in EDI-OCT. We address the problem of combining two orthogonal EDIOCT to improve the en face view of the EDI-OCT scan volume. The combination of two orthogonal scans is solved as an interpolation problem of interpolation from grid lines. We suggest three interpolation methods for solving the problem and we evaluate the performance of each method. We apply the best interpolation method to EDI-OCT data and evaluate the optimized appearance of anatomic structures and reduction of artefacts. At last, we investigate how the 3D quantification of ODD can be used for investigations of ODD complications. We use the new technique OCT Angiography (OCTA), which enables to image the retinal blood flow. We develop a method for quantifying the local vessel density in specific areas around the optic nerve head. We apply the method to EDI-OCT scans of ODD patients and healthy subjects in order to investigate the impact of ODD volume and location on the local vessel density.
Original languageEnglish
PublisherTechnical University of Denmark
Number of pages96
Publication statusPublished - 2020


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