Engineering synergy in biotechnology

Jens Nielsen; Martin Fussenegger; Jay Keasling; Sang Yup Lee; James C. Liao; Kristala Prather; Bernhard Palsson

doi:10.1038/nchembio.1519

Engineering synergy in biotechnology

Jens Nielsen, Martin Fussenegger, Jay Keasling, Sang Yup Lee, James C. Liao, Kristala Prather, Bernhard Palsson

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Abstract

In this article, the author focuses on approaches in metabolic engineering and synthetic biology for the creation of efficient cell factories, which can be bused to convert biomass and other feedstocks for the generation of chemicals. Topics discussed include development of restriction enzymes, engineering plasmids and recyclable markers, production of 1,3-propanediol using a metabolically engineered Escherichia coli and production of isobutanol by using metabolically engineered yeast.

Original language	English
Journal	Nature Chemical Biology
Volume	10
Issue number	5
Pages (from-to)	319-322
Number of pages	4
ISSN	1552-4450
DOIs	https://doi.org/10.1038/nchembio.1519
Publication status	Published - 2014

Keywords

BIOCHEMISTRY
ESCHERICHIA-COLI
STRAIN IMPROVEMENT
SYNTHETIC BIOLOGY
CONSTRUCTION
PATHWAYS
GENOME
SWITCH
SYNTHETIC biology
Research

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title = "Engineering synergy in biotechnology",

abstract = "In this article, the author focuses on approaches in metabolic engineering and synthetic biology for the creation of efficient cell factories, which can be bused to convert biomass and other feedstocks for the generation of chemicals. Topics discussed include development of restriction enzymes, engineering plasmids and recyclable markers, production of 1,3-propanediol using a metabolically engineered Escherichia coli and production of isobutanol by using metabolically engineered yeast.",

keywords = "BIOCHEMISTRY, ESCHERICHIA-COLI, STRAIN IMPROVEMENT, SYNTHETIC BIOLOGY, CONSTRUCTION, PATHWAYS, GENOME, SWITCH, SYNTHETIC biology, Research",

author = "Jens Nielsen and Martin Fussenegger and Jay Keasling and {Yup Lee}, Sang and Liao, {James C.} and Kristala Prather and Bernhard Palsson",

year = "2014",

doi = "10.1038/nchembio.1519",

language = "English",

volume = "10",

pages = "319--322",

journal = "Nature Chemical Biology",

issn = "1552-4450",

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T1 - Engineering synergy in biotechnology

AU - Nielsen, Jens

AU - Fussenegger, Martin

AU - Keasling, Jay

AU - Yup Lee, Sang

AU - Liao, James C.

AU - Prather, Kristala

AU - Palsson, Bernhard

PY - 2014

Y1 - 2014

N2 - In this article, the author focuses on approaches in metabolic engineering and synthetic biology for the creation of efficient cell factories, which can be bused to convert biomass and other feedstocks for the generation of chemicals. Topics discussed include development of restriction enzymes, engineering plasmids and recyclable markers, production of 1,3-propanediol using a metabolically engineered Escherichia coli and production of isobutanol by using metabolically engineered yeast.

AB - In this article, the author focuses on approaches in metabolic engineering and synthetic biology for the creation of efficient cell factories, which can be bused to convert biomass and other feedstocks for the generation of chemicals. Topics discussed include development of restriction enzymes, engineering plasmids and recyclable markers, production of 1,3-propanediol using a metabolically engineered Escherichia coli and production of isobutanol by using metabolically engineered yeast.

KW - BIOCHEMISTRY

KW - ESCHERICHIA-COLI

KW - STRAIN IMPROVEMENT

KW - SYNTHETIC BIOLOGY

KW - CONSTRUCTION

KW - PATHWAYS

KW - GENOME

KW - SWITCH

KW - SYNTHETIC biology

KW - Research

U2 - 10.1038/nchembio.1519

DO - 10.1038/nchembio.1519

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VL - 10

SP - 319

EP - 322

JO - Nature Chemical Biology

JF - Nature Chemical Biology

SN - 1552-4450

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ER -