Engineering microbial fatty acid metabolism for biofuels and biochemicals

Eko Roy Marella; Carina Holkenbrink; Verena Siewers; Irina Borodina

doi:10.1016/j.copbio.2017.10.002

Engineering microbial fatty acid metabolism for biofuels and biochemicals

Eko Roy Marella, Carina Holkenbrink, Verena Siewers, Irina Borodina

Novo Nordisk Foundation Center for Biosustainability

Chalmers University of Technology

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Abstract

Traditional oleochemical industry chemically processes animal fats and plant oils to produce detergents, lubricants, biodiesel, plastics, coatings, and other products. Biotechnology offers an alternative process, where the same oleochemicals can be produced from abundant biomass feedstocks using microbial catalysis. This review summarizes the recent advances in the engineering of microbial metabolism for production of fatty acid-derived products. We highlight the efforts in engineering the central carbon metabolism, redox metabolism, controlling the chain length of the products, and obtaining metabolites with different functionalities. The prospects of commercializing microbial oleochemicals are also discussed.

Original language	English
Journal	Current Opinion in Biotechnology
Volume	50
Pages (from-to)	39-46
ISSN	0958-1669
DOIs	https://doi.org/10.1016/j.copbio.2017.10.002
Publication status	Published - 2017

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PAcMEN: Predictive and Accelerated Metabolic Engineering Network
Nielsen, J. (Project Coordinator), Borodina, I. (Supervisor), Jensen, M. K. (Supervisor), Mortensen, U. H. (Supervisor), Dahlin, J. (PhD Student), Petersen, S. D. (PhD Student), Olsson, H. E. (PhD Student), D'ambrosio, V. (PhD Student), Marella, E. R. (PhD Student), Nurani, W. (PhD Student), Lohmann, R. (Project Manager) & Kjiproski, D. (Project Manager)
Marie Skłodowska-Curie actions
01/10/2016 → 30/09/2020
Project: Research

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abstract = "Traditional oleochemical industry chemically processes animal fats and plant oils to produce detergents, lubricants, biodiesel, plastics, coatings, and other products. Biotechnology offers an alternative process, where the same oleochemicals can be produced from abundant biomass feedstocks using microbial catalysis. This review summarizes the recent advances in the engineering of microbial metabolism for production of fatty acid-derived products. We highlight the efforts in engineering the central carbon metabolism, redox metabolism, controlling the chain length of the products, and obtaining metabolites with different functionalities. The prospects of commercializing microbial oleochemicals are also discussed.",

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AU - Holkenbrink, Carina

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PY - 2017

Y1 - 2017

N2 - Traditional oleochemical industry chemically processes animal fats and plant oils to produce detergents, lubricants, biodiesel, plastics, coatings, and other products. Biotechnology offers an alternative process, where the same oleochemicals can be produced from abundant biomass feedstocks using microbial catalysis. This review summarizes the recent advances in the engineering of microbial metabolism for production of fatty acid-derived products. We highlight the efforts in engineering the central carbon metabolism, redox metabolism, controlling the chain length of the products, and obtaining metabolites with different functionalities. The prospects of commercializing microbial oleochemicals are also discussed.

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DO - 10.1016/j.copbio.2017.10.002

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Engineering microbial fatty acid metabolism for biofuels and biochemicals

Abstract

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PAcMEN: Predictive and Accelerated Metabolic Engineering Network

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