Engineering and systems level analysis of Saccharomyces cerevisiae for production of 3 hydroxypropionic acid via malonyl CoA reductase dependent pathway

Kanchana Rueksomtawin Kildegaard, Niels Bjerg Jensen, Konstantin Schneider, Eik Czarnotta, Emre Özdemir, Tobias Klein, Jerome Maury, Birgitta E. Eber, Hanne Bjerre Christensen, Yun Chen, Il-Kwon Kim, Markus Herrgard, Lars Mathias Blank, Jochen Förster, Jens Nielsen, Irina Borodina

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Abstract

In the future, oil- and gas-derived polymers may be replaced with bio-based polymers, produced from renewable feedstocks using engineered cell factories. Acrylic acid and acrylic esters with an estimated world annual production of approximately 6 million tons by 2017 can be derived from 3-hydroxypropionic acid (3HP), which can be produced by microbial fermentation. For an economically viable process 3HP must be produced at high titer, rate and yield and preferably at low pH to minimize downstream processing costs.
Original languageEnglish
JournalMicrobial Cell Factories
Volume15
Issue number53
Number of pages13
ISSN1475-2859
Publication statusPublished - 2016

Bibliographical note

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.

Keywords

  • 3-Hydroxypropionic acid
  • Saccharomyces cerevisiae
  • Redox metabolism
  • Metabolic engineering

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