Engineered mammalian cells for production of recombinant proteins

Research output: Patent

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The present invention relates to mammalian cells modified to provide for improved expression of a recombinant protein of interest. In particular, the invention relates to CHO cells and other host cells in which the expression of one or more endogenous secreted proteins has been disrupted, as well as to the preparation, identification and use of such cells in the production of recombinant proteins.

Original languageEnglish
IPCC07K 14/ 78 A I
Patent numberWO2017186671
Filing date02/11/2017
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date25/04/2016
Priority numberEP20160166789
Publication statusPublished - 2 Nov 2017


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