Energy consumption in buildings vary significantly, depending on factors as the use of the building, the construction type, maintenance, existing heating, cooling and lighting systems and other types of services. Hotel buildings have high energy consumption rate, as a result of their unique operational characteristics. Energy consumption in hotels is among the highest in the non-residential building sector in absolute values. Available specific information on the energy characteristics, thermal performance, energy losses, electric loads, and comfort conditions play significant role for the sustainable development of hotel's systems. These data can also be used to identify whether there is space for improvement in new or existing hotels by comparing them against predicted or actual building energy performance. The aim of the present paper is to analyze the energy and exergy utilization in four hotels in Rethimno, Crete (Southern Greece) and in Kassandra, Halkidiki (Northern Greece).