Encoding Probabilistic Brain Atlases Using Bayesian Inference

Research output: Contribution to journalJournal articleResearchpeer-review


This paper addresses the problem of creating probabilistic brain atlases from manually labeled training data. Probabilistic atlases are typically constructed by counting the relative frequency of occurrence of labels in corresponding locations across the training images. However, such an ldquoaveragingrdquo approach generalizes poorly to unseen cases when the number of training images is limited, and provides no principled way of aligning the training datasets using deformable registration. In this paper, we generalize the generative image model implicitly underlying standard ldquoaveragerdquo atlases, using mesh-based representations endowed with an explicit deformation model. Bayesian inference is used to infer the optimal model parameters from the training data, leading to a simultaneous group-wise registration and atlas estimation scheme that encompasses standard averaging as a special case. We also use Bayesian inference to compare alternative atlas models in light of the training data, and show how this leads to a data compression problem that is intuitive to interpret and computationally feasible. Using this technique, we automatically determine the optimal amount of spatial blurring, the best deformation field flexibility, and the most compact mesh representation. We demonstrate, using 2-D training datasets, that the resulting models are better at capturing the structure in the training data than conventional probabilistic atlases. We also present experiments of the proposed atlas construction technique in 3-D, and show the resulting atlases' potential in fully-automated, pulse sequence-adaptive segmentation of 36 neuroanatomical structures in brain MRI scans.
Original languageEnglish
JournalI E E E Transactions on Medical Imaging
Issue number6
Pages (from-to)822-837
Number of pages16
Publication statusPublished - 2009
Externally publishedYes


  • Bayes methods
  • biomedical MRI
  • brain
  • data compression
  • image coding
  • image registration
  • image segmentation
  • image sequences
  • medical image processing
  • mesh generation
  • neurophysiology
  • Algorithms
  • Artificial Intelligence
  • Bayes Theorem
  • Brain
  • Brain Mapping
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Markov Chains
  • Models, Statistical
  • Reproducibility of Results


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