Encapsulation of Water-Insoluble Drugs in Polymer Capsules Prepared Using Mesoporous Silica Templates for Intracellular Drug Delivery

Yajun Wang; Yan Yan; Jiwei Cui; Leticia Hosta Rigau; Joan K. Heath; Edouard C. Nice; Frank Caruso

doi:10.1002/adma.201001497

Encapsulation of Water-Insoluble Drugs in Polymer Capsules Prepared Using Mesoporous Silica Templates for Intracellular Drug Delivery

Yajun Wang, Yan Yan, Jiwei Cui, Leticia Hosta Rigau, Joan K. Heath, Edouard C. Nice, Frank Caruso

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Water-insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle-mediated layer-by-layer assembly. The drug-loaded capsules exhibit excellent colloidal stability and high potency to colorectal cancer cells in vitro with similar cytotoxicity to the free drug dissolved in organic solvent.

Original language	English
Journal	Advanced Materials
Volume	22
Issue number	38
Pages (from-to)	4293-4297
Number of pages	5
ISSN	0935-9648
DOIs	https://doi.org/10.1002/adma.201001497
Publication status	Published - 2010
Externally published	Yes

Keywords

CHEMISTRY,
NANOSCIENCE
MATERIALS
PHYSICS,
COLORECTAL-CANCER CELLS
MULTILAYERED PARTICLES
NANOPARTICLES
SPHERES
MICROCAPSULES
THERAPEUTICS
RELEASE
BINDING
SYSTEMS
ASSAYS
Antineoplastic Agents, Phytogenic
Capsules
Cell Line, Tumor
Depsipeptides
Drug Carriers
Humans
Nanoparticles
Paclitaxel
Polymers
Porosity
Silicon Dioxide
Water
thiocoraline
Drug delivery
Organic solvents
Silica
Encapsulation
antineoplastic agent
depsipeptide
drug carrier
nanoparticle
paclitaxel
polymer
silicon dioxide
water
article
chemistry
human
microcapsule
porosity
tumor cell line
ultrastructure
Colloidal Stability
Colorectal cancer cell
High potency
In-vitro
Insoluble compounds
Insoluble drug
Intracellular drug delivery
Layer-by-layer assemblies
Mesoporous Silica
Mesoporous silica nanoparticles
Polymer capsules
Polymer capsule
Layer‐by‐layer
Mesoporous silica
Water‐insoluble drug

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adma.201001497

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title = "Encapsulation of Water-Insoluble Drugs in Polymer Capsules Prepared Using Mesoporous Silica Templates for Intracellular Drug Delivery",

abstract = "Water-insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle-mediated layer-by-layer assembly. The drug-loaded capsules exhibit excellent colloidal stability and high potency to colorectal cancer cells in vitro with similar cytotoxicity to the free drug dissolved in organic solvent.",

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author = "Yajun Wang and Yan Yan and Jiwei Cui and Rigau, {Leticia Hosta} and Heath, {Joan K.} and Nice, {Edouard C.} and Frank Caruso",

year = "2010",

doi = "10.1002/adma.201001497",

language = "English",

volume = "22",

pages = "4293--4297",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley",

number = "38",

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T1 - Encapsulation of Water-Insoluble Drugs in Polymer Capsules Prepared Using Mesoporous Silica Templates for Intracellular Drug Delivery

AU - Wang, Yajun

AU - Yan, Yan

AU - Cui, Jiwei

AU - Rigau, Leticia Hosta

AU - Heath, Joan K.

AU - Nice, Edouard C.

AU - Caruso, Frank

PY - 2010

Y1 - 2010

N2 - Water-insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle-mediated layer-by-layer assembly. The drug-loaded capsules exhibit excellent colloidal stability and high potency to colorectal cancer cells in vitro with similar cytotoxicity to the free drug dissolved in organic solvent.

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KW - CHEMISTRY,

KW - NANOSCIENCE

KW - MATERIALS

KW - PHYSICS,

KW - COLORECTAL-CANCER CELLS

KW - MULTILAYERED PARTICLES

KW - NANOPARTICLES

KW - SPHERES

KW - MICROCAPSULES

KW - THERAPEUTICS

KW - RELEASE

KW - BINDING

KW - SYSTEMS

KW - ASSAYS

KW - Antineoplastic Agents, Phytogenic

KW - Capsules

KW - Cell Line, Tumor

KW - Depsipeptides

KW - Drug Carriers

KW - Humans

KW - Nanoparticles

KW - Paclitaxel

KW - Polymers

KW - Porosity

KW - Silicon Dioxide

KW - Water

KW - thiocoraline

KW - Drug delivery

KW - Organic solvents

KW - Silica

KW - Encapsulation

KW - antineoplastic agent

KW - depsipeptide

KW - drug carrier

KW - nanoparticle

KW - paclitaxel

KW - polymer

KW - silicon dioxide

KW - water

KW - article

KW - chemistry

KW - human

KW - microcapsule

KW - porosity

KW - tumor cell line

KW - ultrastructure

KW - Colloidal Stability

KW - Colorectal cancer cell

KW - High potency

KW - In-vitro

KW - Insoluble compounds

KW - Insoluble drug

KW - Intracellular drug delivery

KW - Layer-by-layer assemblies

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KW - Mesoporous silica nanoparticles

KW - Polymer capsules

KW - Polymer capsule

KW - Layer‐by‐layer

KW - Mesoporous silica

KW - Water‐insoluble drug

U2 - 10.1002/adma.201001497

DO - 10.1002/adma.201001497

M3 - Journal article

C2 - 20564713

SN - 0935-9648

VL - 22

SP - 4293

EP - 4297

JO - Advanced Materials

JF - Advanced Materials

IS - 38

ER -

Encapsulation of Water-Insoluble Drugs in Polymer Capsules Prepared Using Mesoporous Silica Templates for Intracellular Drug Delivery

Abstract

Keywords

UN SDGs

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