Encapsulation of Water-Insoluble Drugs in Polymer Capsules Prepared Using Mesoporous Silica Templates for Intracellular Drug Delivery

Yajun Wang, Yan Yan, Jiwei Cui, Leticia Hosta Rigau, Joan K. Heath, Edouard C. Nice, Frank Caruso

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Water-insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle-mediated layer-by-layer assembly. The drug-loaded capsules exhibit excellent colloidal stability and high potency to colorectal cancer cells in vitro with similar cytotoxicity to the free drug dissolved in organic solvent.
Original languageEnglish
JournalAdvanced Materials
Volume22
Issue number38
Pages (from-to)4293-4297
Number of pages5
ISSN0935-9648
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • CHEMISTRY,
  • NANOSCIENCE
  • MATERIALS
  • PHYSICS,
  • COLORECTAL-CANCER CELLS
  • MULTILAYERED PARTICLES
  • NANOPARTICLES
  • SPHERES
  • MICROCAPSULES
  • THERAPEUTICS
  • RELEASE
  • BINDING
  • SYSTEMS
  • ASSAYS
  • Antineoplastic Agents, Phytogenic
  • Capsules
  • Cell Line, Tumor
  • Depsipeptides
  • Drug Carriers
  • Humans
  • Nanoparticles
  • Paclitaxel
  • Polymers
  • Porosity
  • Silicon Dioxide
  • Water
  • thiocoraline
  • Drug delivery
  • Organic solvents
  • Silica
  • Encapsulation
  • antineoplastic agent
  • depsipeptide
  • drug carrier
  • nanoparticle
  • paclitaxel
  • polymer
  • silicon dioxide
  • water
  • article
  • chemistry
  • human
  • microcapsule
  • porosity
  • tumor cell line
  • ultrastructure
  • Colloidal Stability
  • Colorectal cancer cell
  • High potency
  • In-vitro
  • Insoluble compounds
  • Insoluble drug
  • Intracellular drug delivery
  • Layer-by-layer assemblies
  • Mesoporous Silica
  • Mesoporous silica nanoparticles
  • Polymer capsules
  • Polymer capsule
  • Layer‐by‐layer
  • Mesoporous silica
  • Water‐insoluble drug

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