Encapsulation of water insoluble drugs in mesoporous silica nanoparticles using supercritical carbon dioxide

A. Patil, U. N. Chirmade, Vivek Trivedi, D. A. Lamprou, Andrew Urquhart, D. Douroumis

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Abstract

Mesoporous silica nanoparticles MCM - 41 were synthesized with two dimensional hexagonal p6mm symmetry, high specific surface area(~ 980m2/g) narrow pore size and an average particle size of 186 nm. The produced nanoparticles were used to encapsulate carbamazepine through a supercritical carbon dioxide process combined with various organic solvents. Supercritical processing was found to provide increased drug encapsulation. The loaded MCM - 41 nanoparticles were analyzed using X-ray diffraction and differential scanning calorimetry (DSC) to investigate the crystalline state of the encapsulated carbamazepine and it was found to be dependent on the nature of the organic solvent. Carbamazepine showed increased dissolution rates under sink conditions. Viability studies of Caco - 2 cells demonstrated negligible cytotoxicity for the MCM-41 nanoparticles. © 2011 Patil A, et al.
Original languageEnglish
JournalJournal of Nanomedicine & Nanotechnology
Volume2
Issue number3
ISSN2157-7439
DOIs
Publication statusPublished - 2011
Externally publishedYes

Bibliographical note

Creative Commons Attribution Licence

Keywords

  • Cytotoxicity
  • Drug solubility
  • Loading
  • Mesoporous silica
  • Nanoparticles
  • Supercritical fluids

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