Abstract
Biological macromolecules can be encapsulated into preformed polymersomes by controlled temporary destabilization of the vesicle membrane. The morphology and the size of the polymersome are unchanged after electroporation, suggesting that the polymersome membrane is reformed. The surface charge of the biomacromolecules plays a key role for the electroporation process.
Original language | English |
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Journal | Angewandte chemie-international edition |
Volume | 51 |
Issue number | 44 |
Pages (from-to) | 11122-11125 |
Number of pages | 4 |
ISSN | 1433-7851 |
DOIs | |
Publication status | Published - 2012 |
Externally published | Yes |
Keywords
- Drug delivery
- Electroporation
- Encapsulation
- Gene therapy
- Polymersomes