Encapsulation of Biomacromolecules within Polymersomes by Electroporation

Linge Wang, Luca Chierico, Daniel Little, Nisa Patikarnmonthon, Zhou Yang, Mimoun Azzouz, Peter Jeppe Madsen, Steven P. Armes, Giuseppe Battaglia

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Biological macromolecules can be encapsulated into preformed polymersomes by controlled temporary destabilization of the vesicle membrane. The morphology and the size of the polymersome are unchanged after electroporation, suggesting that the polymersome membrane is reformed. The surface charge of the biomacromolecules plays a key role for the electroporation process. 
Original languageEnglish
JournalAngewandte chemie-international edition
Volume51
Issue number44
Pages (from-to)11122-11125
Number of pages4
ISSN1433-7851
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Drug delivery
  • Electroporation
  • Encapsulation
  • Gene therapy
  • Polymersomes

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