Biological macromolecules can be encapsulated into preformed polymersomes by controlled temporary destabilization of the vesicle membrane. The morphology and the size of the polymersome are unchanged after electroporation, suggesting that the polymersome membrane is reformed. The surface charge of the biomacromolecules plays a key role for the electroporation process.
|Journal||Angewandte chemie-international edition|
|Number of pages||4|
|Publication status||Published - 2012|
- Drug delivery
- Gene therapy