Enantioselective γ-Lactam Synthesis via Palladium-Catalyzed Intramolecular Asymmetric Allylic Alkylation

Xavier Bantreil; Guillaume Prestat; David Madec; Peter Fristrup; Giovanni Poli

doi:10.1055/s-0029-1216747

Enantioselective γ-Lactam Synthesis via Palladium-Catalyzed Intramolecular Asymmetric Allylic Alkylation

Xavier Bantreil, Guillaume Prestat, David Madec, Peter Fristrup, Giovanni Poli

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A Pd(0)-catalyzed intramolecular allylic alkylation in the presence of (R)-3,5-t-Bu-MeOBIPHEP takes place in up to 92:8 er in agreement with DFT calculations and provides easy access to enantioenriched disubstituted g-lactams.
Keyword: Enantioselectivity,Allylic alkylation,Palladium

Original language	English
Journal	SYNLETT: Accounts and Rapid Communications in Chemical Synthesis
Volume	9
Issue number	1441
Pages (from-to)	G04709ST
ISSN	0936-5214
DOIs	https://doi.org/10.1055/s-0029-1216747
Publication status	Published - 2009
Externally published	Yes

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title = "Enantioselective γ-Lactam Synthesis via Palladium-Catalyzed Intramolecular Asymmetric Allylic Alkylation",

abstract = "A Pd(0)-catalyzed intramolecular allylic alkylation in the presence of (R)-3,5-t-Bu-MeOBIPHEP takes place in up to 92:8 er in agreement with DFT calculations and provides easy access to enantioenriched disubstituted g-lactams. Keyword: Enantioselectivity,Allylic alkylation,Palladium",

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year = "2009",

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issn = "0936-5214",

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T1 - Enantioselective γ-Lactam Synthesis via Palladium-Catalyzed Intramolecular Asymmetric Allylic Alkylation

AU - Bantreil, Xavier

AU - Prestat, Guillaume

AU - Madec, David

AU - Fristrup, Peter

AU - Poli, Giovanni

PY - 2009

Y1 - 2009

N2 - A Pd(0)-catalyzed intramolecular allylic alkylation in the presence of (R)-3,5-t-Bu-MeOBIPHEP takes place in up to 92:8 er in agreement with DFT calculations and provides easy access to enantioenriched disubstituted g-lactams. Keyword: Enantioselectivity,Allylic alkylation,Palladium

AB - A Pd(0)-catalyzed intramolecular allylic alkylation in the presence of (R)-3,5-t-Bu-MeOBIPHEP takes place in up to 92:8 er in agreement with DFT calculations and provides easy access to enantioenriched disubstituted g-lactams. Keyword: Enantioselectivity,Allylic alkylation,Palladium

U2 - 10.1055/s-0029-1216747

DO - 10.1055/s-0029-1216747

M3 - Journal article

VL - 9

SP - G04709ST

JO - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis

JF - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis

SN - 0936-5214

IS - 1441

ER -

Enantioselective γ-Lactam Synthesis via Palladium-Catalyzed Intramolecular Asymmetric Allylic Alkylation

Abstract

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