TY - JOUR
T1 - Emerging trends in the discovery of natural product antibacterials
AU - Bologa, Cristian G
AU - Ursu, Oleg
AU - Oprea, Tudor
AU - Melançon, Charles E, III
AU - Tegos, George P
PY - 2013
Y1 - 2013
N2 - This article highlights current trends and advances in exploiting natural sources for the deployment of novel and potent anti-infective countermeasures. The key challenge is to therapeutically target bacterial pathogens that exhibit a variety of puzzling and evolutionarily complex resistance mechanisms. Special emphasis is given to the strengths, weaknesses, and opportunities in the natural product antibacterial drug discovery arena, and to emerging applications driven by advances in bioinformatics, chemical biology, and synthetic biology in concert with exploiting bacterial phenotypes. These efforts have identified a critical mass of natural product antibacterial lead compounds and discovery technologies with high probability of successful implementation against emerging bacterial pathogens.
AB - This article highlights current trends and advances in exploiting natural sources for the deployment of novel and potent anti-infective countermeasures. The key challenge is to therapeutically target bacterial pathogens that exhibit a variety of puzzling and evolutionarily complex resistance mechanisms. Special emphasis is given to the strengths, weaknesses, and opportunities in the natural product antibacterial drug discovery arena, and to emerging applications driven by advances in bioinformatics, chemical biology, and synthetic biology in concert with exploiting bacterial phenotypes. These efforts have identified a critical mass of natural product antibacterial lead compounds and discovery technologies with high probability of successful implementation against emerging bacterial pathogens.
U2 - 10.1016/j.coph.2013.07.002
DO - 10.1016/j.coph.2013.07.002
M3 - Journal article
C2 - 23890825
SN - 1471-4892
VL - 13
SP - 678
EP - 687
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 5
ER -