Emerging trends in the discovery of natural product antibacterials

Cristian G Bologa, Oleg Ursu, Tudor Oprea, Charles E, III Melançon, George P Tegos

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    This article highlights current trends and advances in exploiting natural sources for the deployment of novel and potent anti-infective countermeasures. The key challenge is to therapeutically target bacterial pathogens that exhibit a variety of puzzling and evolutionarily complex resistance mechanisms. Special emphasis is given to the strengths, weaknesses, and opportunities in the natural product antibacterial drug discovery arena, and to emerging applications driven by advances in bioinformatics, chemical biology, and synthetic biology in concert with exploiting bacterial phenotypes. These efforts have identified a critical mass of natural product antibacterial lead compounds and discovery technologies with high probability of successful implementation against emerging bacterial pathogens.
    Original languageEnglish
    JournalCurrent Opinion in Pharmacology
    Volume13
    Issue number5
    Pages (from-to)678-687
    ISSN1471-4892
    DOIs
    Publication statusPublished - 2013

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