Emerging immunomodulatory strategies for cell therapeutics

Corrine Ying Xuan Chua; Allen Yujie Jiang; Tatiane Eufrásio-da-Silva; Alireza Dolatshahi-Pirouz; Robert Langer; Gorka Orive; Alessandro Grattoni

doi:10.1016/j.tibtech.2022.11.008

Emerging immunomodulatory strategies for cell therapeutics

Corrine Ying Xuan Chua
, Allen Yujie Jiang
, Tatiane Eufrásio-da-Silva
, Alireza Dolatshahi-Pirouz
, Robert Langer
, Gorka Orive
, Alessandro Grattoni

Department of Health Technology

Houston Methodist Research Institute
Massachusetts Institute of Technology
University of the Basque Country

Research output: Contribution to journal › Review › peer-review

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Abstract

Cellular therapies are poised to transform the field of medicine by restoringdysfunctional tissues and treating various diseases in a dynamic manner notachievable by conventional pharmaceutics. Spanning various therapeuticareas inclusive of cancer, regenerative medicine, and immune disorders, cellulartherapies comprise stem or non-stem cells derived from various sources. Despite numerous clinical approvals or trials underway, the host immune responsepresents a critical impediment to the widespread adoption and success of cellular therapies. Here, we review current research and clinical advances in immunomodulatory strategies to mitigate immune rejection or promote immunetolerance to cellular therapies. We discuss the potential of these immunomodulatory interventions to accelerate translation or maximize the prospects of improving therapeutic outcomes of cellular therapies for clinical success.

Original language	English
Journal	Trends in Biotechnology
Volume	41
Issue number	3
Pages (from-to)	358-373
ISSN	0167-7799
DOIs	https://doi.org/10.1016/j.tibtech.2022.11.008
Publication status	Published - 2023

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SDG 3 Good Health and Well-being

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T1 - Emerging immunomodulatory strategies for cell therapeutics

AU - Chua, Corrine Ying Xuan

AU - Jiang, Allen Yujie

AU - Eufrásio-da-Silva, Tatiane

AU - Dolatshahi-Pirouz, Alireza

AU - Langer, Robert

AU - Orive, Gorka

AU - Grattoni, Alessandro

PY - 2023

Y1 - 2023

N2 - Cellular therapies are poised to transform the field of medicine by restoringdysfunctional tissues and treating various diseases in a dynamic manner notachievable by conventional pharmaceutics. Spanning various therapeuticareas inclusive of cancer, regenerative medicine, and immune disorders, cellulartherapies comprise stem or non-stem cells derived from various sources. Despite numerous clinical approvals or trials underway, the host immune responsepresents a critical impediment to the widespread adoption and success of cellular therapies. Here, we review current research and clinical advances in immunomodulatory strategies to mitigate immune rejection or promote immunetolerance to cellular therapies. We discuss the potential of these immunomodulatory interventions to accelerate translation or maximize the prospects of improving therapeutic outcomes of cellular therapies for clinical success.

AB - Cellular therapies are poised to transform the field of medicine by restoringdysfunctional tissues and treating various diseases in a dynamic manner notachievable by conventional pharmaceutics. Spanning various therapeuticareas inclusive of cancer, regenerative medicine, and immune disorders, cellulartherapies comprise stem or non-stem cells derived from various sources. Despite numerous clinical approvals or trials underway, the host immune responsepresents a critical impediment to the widespread adoption and success of cellular therapies. Here, we review current research and clinical advances in immunomodulatory strategies to mitigate immune rejection or promote immunetolerance to cellular therapies. We discuss the potential of these immunomodulatory interventions to accelerate translation or maximize the prospects of improving therapeutic outcomes of cellular therapies for clinical success.

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DO - 10.1016/j.tibtech.2022.11.008

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VL - 41

SP - 358

EP - 373

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 3

ER -

Emerging immunomodulatory strategies for cell therapeutics

Abstract

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