TY - JOUR
T1 - Emerging immunomodulatory strategies for cell therapeutics
AU - Chua, Corrine Ying Xuan
AU - Jiang, Allen Yujie
AU - Eufrásio-da-Silva, Tatiane
AU - Dolatshahi-Pirouz, Alireza
AU - Langer, Robert
AU - Orive, Gorka
AU - Grattoni, Alessandro
PY - 2023
Y1 - 2023
N2 - Cellular therapies are poised to transform the field of medicine by restoringdysfunctional tissues and treating various diseases in a dynamic manner notachievable by conventional pharmaceutics. Spanning various therapeuticareas inclusive of cancer, regenerative medicine, and immune disorders, cellulartherapies comprise stem or non-stem cells derived from various sources. Despite numerous clinical approvals or trials underway, the host immune responsepresents a critical impediment to the widespread adoption and success of cellular therapies. Here, we review current research and clinical advances in immunomodulatory strategies to mitigate immune rejection or promote immunetolerance to cellular therapies. We discuss the potential of these immunomodulatory interventions to accelerate translation or maximize the prospects of improving therapeutic outcomes of cellular therapies for clinical success.
AB - Cellular therapies are poised to transform the field of medicine by restoringdysfunctional tissues and treating various diseases in a dynamic manner notachievable by conventional pharmaceutics. Spanning various therapeuticareas inclusive of cancer, regenerative medicine, and immune disorders, cellulartherapies comprise stem or non-stem cells derived from various sources. Despite numerous clinical approvals or trials underway, the host immune responsepresents a critical impediment to the widespread adoption and success of cellular therapies. Here, we review current research and clinical advances in immunomodulatory strategies to mitigate immune rejection or promote immunetolerance to cellular therapies. We discuss the potential of these immunomodulatory interventions to accelerate translation or maximize the prospects of improving therapeutic outcomes of cellular therapies for clinical success.
U2 - 10.1016/j.tibtech.2022.11.008
DO - 10.1016/j.tibtech.2022.11.008
M3 - Review
C2 - 36549959
SN - 0167-7799
VL - 41
SP - 358
EP - 373
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 3
ER -
