Cellular therapies are poised to transform the field of medicine by restoringdysfunctional tissues and treating various diseases in a dynamic manner notachievable by conventional pharmaceutics. Spanning various therapeuticareas inclusive of cancer, regenerative medicine, and immune disorders, cellulartherapies comprise stem or non-stem cells derived from various sources. Despite numerous clinical approvals or trials underway, the host immune responsepresents a critical impediment to the widespread adoption and success of cellular therapies. Here, we review current research and clinical advances in immunomodulatory strategies to mitigate immune rejection or promote immunetolerance to cellular therapies. We discuss the potential of these immunomodulatory interventions to accelerate translation or maximize the prospects of improving therapeutic outcomes of cellular therapies for clinical success.