Emerging Biofabrication Strategies for Engineering Complex Tissue Constructs

R. Daniel Pedde, Bahram Mirani, Ali Navaei, Tara Styan, Sarah Wong, Mehdi Mehrali, Ashish Thakur, Nima Khadem Mohtaram, Armin Bayati, Alireza Dolatshahi-Pirouz, Mehdi Nikkhah, Stephanie M. Willerth, Mohsen Akbari

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The demand for organ transplantation and repair, coupled with a shortage of available donors, poses an urgent clinical need for the development of innovative treatment strategies for long-term repair and regeneration of injured or diseased tissues and organs. Bioengineering organs, by growing patient-derived cells in biomaterial scaffolds in the presence of pertinent physicochemical signals, provides a promising solution to meet this demand. However, recapitulating the structural and cytoarchitectural complexities of native tissues in vitro remains a significant challenge to be addressed. Through tremendous efforts over the past decade, several innovative biofabrication strategies have been developed to overcome these challenges. This review highlights recent work on emerging three-dimensional bioprinting and textile techniques, compares the advantages and shortcomings of these approaches, outlines the use of common biomaterials and advanced hybrid scaffolds, and describes several design considerations including the structural, physical, biological, and economical parameters that are crucial for the fabrication of functional, complex, engineered tissues. Finally, the applications of these biofabrication strategies in neural, skin, connective, and muscle tissue engineering are explored.
    Original languageEnglish
    Article number1606061
    JournalAdvanced Materials
    Volume29
    Issue number19
    Number of pages27
    ISSN0935-9648
    DOIs
    Publication statusPublished - 2017

    Keywords

    • 3D printing
    • biofabrication
    • regenerative medicine
    • textiles
    • tissue engineering

    Cite this

    Pedde, R. D., Mirani, B., Navaei, A., Styan, T., Wong, S., Mehrali, M., Thakur, A., Mohtaram, N. K., Bayati, A., Dolatshahi-Pirouz, A., Nikkhah, M., Willerth, S. M., & Akbari, M. (2017). Emerging Biofabrication Strategies for Engineering Complex Tissue Constructs. Advanced Materials, 29(19), [1606061]. https://doi.org/10.1002/adma.201606061