Elucidation of the biosynthesis of meroterpenoid yanuthone D in Aspergillus Niger

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Abstract

We have elucidated the mode of biosynthesis of the meroterpenoid compound Yanuthone D in Aspergillus niger. We have successfully deleted all cluster genes, and identified a number of intermediates. Structures of the intermediates were solved using a combined approach comprising classical 1D- and 2D-NMR and tandem mass spectrometry (MS/MS). In this study we have confirmed that Yanuthone D is of meroterpenoid origin, and we have identified an unexpected precursor, which has not before been reported for Aspergillus niger.
Original languageEnglish
JournalPlanta Medica
Volume78
Issue number11
Pages (from-to)1069-1069
ISSN0032-0943
DOIs
Publication statusPublished - 2012
EventInternational Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF - New York, NY, United States
Duration: 28 Jul 20121 Aug 2012

Conference

ConferenceInternational Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF
CountryUnited States
CityNew York, NY
Period28/07/201201/08/2012

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