Abstract
We have elucidated the mode of biosynthesis of the meroterpenoid compound Yanuthone D in Aspergillus niger. We have successfully deleted all cluster genes, and identified a number of intermediates. Structures of the intermediates were solved using a combined approach comprising classical 1D- and 2D-NMR and tandem mass spectrometry (MS/MS). In this study we have confirmed that Yanuthone D is of meroterpenoid origin, and we have identified an unexpected precursor, which has not before been reported for Aspergillus niger.
Original language | English |
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Journal | Planta Medica |
Volume | 78 |
Issue number | 11 |
Pages (from-to) | 1069-1069 |
ISSN | 0032-0943 |
DOIs | |
Publication status | Published - 2012 |
Event | International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF - New York, NY, United States Duration: 28 Jul 2012 → 1 Aug 2012 |
Conference
Conference | International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF |
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Country/Territory | United States |
City | New York, NY |
Period | 28/07/2012 → 01/08/2012 |