Elucidation of the biosynthesis of meroterpenoid yanuthone D in Aspergillus Niger

Dorte Koefoed Holm; Lene Maj Petersen; Andreas Klitgaard; Zofia Dorota Jarczynska; Thomas Ostenfeld Larsen; Uffe Hasbro Mortensen

doi:10.1055/s-0032-1320343

Elucidation of the biosynthesis of meroterpenoid yanuthone D in Aspergillus Niger

Dorte Koefoed Holm, Lene Maj Petersen, Andreas Klitgaard, Zofia Dorota Jarczynska, Thomas Ostenfeld Larsen, Uffe Hasbro Mortensen

Department of Chemistry

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Abstract

We have elucidated the mode of biosynthesis of the meroterpenoid compound Yanuthone D in Aspergillus niger. We have successfully deleted all cluster genes, and identified a number of intermediates. Structures of the intermediates were solved using a combined approach comprising classical 1D- and 2D-NMR and tandem mass spectrometry (MS/MS). In this study we have confirmed that Yanuthone D is of meroterpenoid origin, and we have identified an unexpected precursor, which has not before been reported for Aspergillus niger.

Original language	English
Journal	Planta Medica
Volume	78
Issue number	11
Pages (from-to)	1069-1069
ISSN	0032-0943
DOIs	https://doi.org/10.1055/s-0032-1320343
Publication status	Published - 2012
Event	International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF - New York, NY, United States Duration: 28 Jul 2012 → 1 Aug 2012

Conference

Conference	International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF
Country	United States
City	New York, NY
Period	28/07/2012 → 01/08/2012

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10.1055/s-0032-1320343

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title = "Elucidation of the biosynthesis of meroterpenoid yanuthone D in Aspergillus Niger",

abstract = "We have elucidated the mode of biosynthesis of the meroterpenoid compound Yanuthone D in Aspergillus niger. We have successfully deleted all cluster genes, and identified a number of intermediates. Structures of the intermediates were solved using a combined approach comprising classical 1D- and 2D-NMR and tandem mass spectrometry (MS/MS). In this study we have confirmed that Yanuthone D is of meroterpenoid origin, and we have identified an unexpected precursor, which has not before been reported for Aspergillus niger.",

author = "Holm, {Dorte Koefoed} and Petersen, {Lene Maj} and Andreas Klitgaard and Jarczynska, {Zofia Dorota} and Larsen, {Thomas Ostenfeld} and Mortensen, {Uffe Hasbro}",

year = "2012",

doi = "10.1055/s-0032-1320343",

language = "English",

volume = "78",

pages = "1069--1069",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "GeorgThieme Verlag",

number = "11",

note = "International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF ; Conference date: 28-07-2012 Through 01-08-2012",

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Elucidation of the biosynthesis of meroterpenoid yanuthone D in Aspergillus Niger. / Holm, Dorte Koefoed; Petersen, Lene Maj; Klitgaard, Andreas; Jarczynska, Zofia Dorota ; Larsen, Thomas Ostenfeld ; Mortensen, Uffe Hasbro.

In: Planta Medica, Vol. 78, No. 11, 2012, p. 1069-1069.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

TY - ABST

T1 - Elucidation of the biosynthesis of meroterpenoid yanuthone D in Aspergillus Niger

AU - Holm, Dorte Koefoed

AU - Petersen, Lene Maj

AU - Klitgaard, Andreas

AU - Jarczynska, Zofia Dorota

AU - Larsen, Thomas Ostenfeld

AU - Mortensen, Uffe Hasbro

PY - 2012

Y1 - 2012

N2 - We have elucidated the mode of biosynthesis of the meroterpenoid compound Yanuthone D in Aspergillus niger. We have successfully deleted all cluster genes, and identified a number of intermediates. Structures of the intermediates were solved using a combined approach comprising classical 1D- and 2D-NMR and tandem mass spectrometry (MS/MS). In this study we have confirmed that Yanuthone D is of meroterpenoid origin, and we have identified an unexpected precursor, which has not before been reported for Aspergillus niger.

AB - We have elucidated the mode of biosynthesis of the meroterpenoid compound Yanuthone D in Aspergillus niger. We have successfully deleted all cluster genes, and identified a number of intermediates. Structures of the intermediates were solved using a combined approach comprising classical 1D- and 2D-NMR and tandem mass spectrometry (MS/MS). In this study we have confirmed that Yanuthone D is of meroterpenoid origin, and we have identified an unexpected precursor, which has not before been reported for Aspergillus niger.

U2 - 10.1055/s-0032-1320343

DO - 10.1055/s-0032-1320343

M3 - Conference abstract in journal

VL - 78

SP - 1069

EP - 1069

JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 11

T2 - International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF

Y2 - 28 July 2012 through 1 August 2012

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