Electrospun Xanthan gum-Chitosan nanofibers as delivery carrier of hydrophobic bioactives

Elhamalsadat Shekarforoush, Fatemeh Ajalloueian, Guanghong Zeng, Ana Carina Loureiro Mendes*, Ioannis S. Chronakis

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Viscoelastic gels of xanthan gum-chitosan(X-Ch) were electrospun to produce nanofibers, stable in aqueous media, for the encapsulation and release of curcumin (Cu). After 120h, the nanofibers released lower amount of curcumin (∼20%) at pH 2.2 comparatively to the release in neutral media (∼50%), suggesting that X-Ch nanofibers could be used as a carrier for the encapsulation of hydrophobic bioactive compounds with long-term pH-stimulated release properties.
Original languageEnglish
JournalMaterials Letters
Volume228
Pages (from-to)322-326
ISSN0167-577X
DOIs
Publication statusPublished - 2018

Keywords

  • Xanthan gum
  • Chitosan
  • Electrospinning
  • Drug delivery
  • Curcumin

Cite this

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title = "Electrospun Xanthan gum-Chitosan nanofibers as delivery carrier of hydrophobic bioactives",
abstract = "Viscoelastic gels of xanthan gum-chitosan(X-Ch) were electrospun to produce nanofibers, stable in aqueous media, for the encapsulation and release of curcumin (Cu). After 120h, the nanofibers released lower amount of curcumin (∼20{\%}) at pH 2.2 comparatively to the release in neutral media (∼50{\%}), suggesting that X-Ch nanofibers could be used as a carrier for the encapsulation of hydrophobic bioactive compounds with long-term pH-stimulated release properties.",
keywords = "Xanthan gum, Chitosan, Electrospinning, Drug delivery, Curcumin",
author = "Elhamalsadat Shekarforoush and Fatemeh Ajalloueian and Guanghong Zeng and Mendes, {Ana Carina Loureiro} and Chronakis, {Ioannis S.}",
year = "2018",
doi = "10.1016/j.matlet.2018.06.033",
language = "English",
volume = "228",
pages = "322--326",
journal = "Materials Letters",
issn = "0167-577X",
publisher = "Elsevier",

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Electrospun Xanthan gum-Chitosan nanofibers as delivery carrier of hydrophobic bioactives. / Shekarforoush, Elhamalsadat; Ajalloueian, Fatemeh; Zeng, Guanghong; Mendes, Ana Carina Loureiro; Chronakis, Ioannis S.

In: Materials Letters, Vol. 228, 2018, p. 322-326.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Electrospun Xanthan gum-Chitosan nanofibers as delivery carrier of hydrophobic bioactives

AU - Shekarforoush, Elhamalsadat

AU - Ajalloueian, Fatemeh

AU - Zeng, Guanghong

AU - Mendes, Ana Carina Loureiro

AU - Chronakis, Ioannis S.

PY - 2018

Y1 - 2018

N2 - Viscoelastic gels of xanthan gum-chitosan(X-Ch) were electrospun to produce nanofibers, stable in aqueous media, for the encapsulation and release of curcumin (Cu). After 120h, the nanofibers released lower amount of curcumin (∼20%) at pH 2.2 comparatively to the release in neutral media (∼50%), suggesting that X-Ch nanofibers could be used as a carrier for the encapsulation of hydrophobic bioactive compounds with long-term pH-stimulated release properties.

AB - Viscoelastic gels of xanthan gum-chitosan(X-Ch) were electrospun to produce nanofibers, stable in aqueous media, for the encapsulation and release of curcumin (Cu). After 120h, the nanofibers released lower amount of curcumin (∼20%) at pH 2.2 comparatively to the release in neutral media (∼50%), suggesting that X-Ch nanofibers could be used as a carrier for the encapsulation of hydrophobic bioactive compounds with long-term pH-stimulated release properties.

KW - Xanthan gum

KW - Chitosan

KW - Electrospinning

KW - Drug delivery

KW - Curcumin

U2 - 10.1016/j.matlet.2018.06.033

DO - 10.1016/j.matlet.2018.06.033

M3 - Journal article

VL - 228

SP - 322

EP - 326

JO - Materials Letters

JF - Materials Letters

SN - 0167-577X

ER -