Electrospun Xanthan gum-Chitosan nanofibers as delivery carrier of hydrophobic bioactives

Elhamalsadat Shekarforoush, Fatemeh Ajalloueian, Guanghong Zeng, Ana Carina Loureiro Mendes*, Ioannis S. Chronakis

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Viscoelastic gels of xanthan gum-chitosan(X-Ch) were electrospun to produce nanofibers, stable in aqueous media, for the encapsulation and release of curcumin (Cu). After 120h, the nanofibers released lower amount of curcumin (∼20%) at pH 2.2 comparatively to the release in neutral media (∼50%), suggesting that X-Ch nanofibers could be used as a carrier for the encapsulation of hydrophobic bioactive compounds with long-term pH-stimulated release properties.
Original languageEnglish
JournalMaterials Letters
Volume228
Pages (from-to)322-326
ISSN0167-577X
DOIs
Publication statusPublished - 2018

Keywords

  • Xanthan gum
  • Chitosan
  • Electrospinning
  • Drug delivery
  • Curcumin

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