Electrochemistry of complex molecular and biomolecular scale entities

Christian Engelbrekt, Dmitrii Glukhov, Yueqi Li, Renat R. Nazmutdinov, Jing Tang, Jens Ulstrup*, Zixiao Wang, Xinxin Xiao, Jiawei Yan, Xiaomei Yan, Tamara Zinkicheva

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Structural mapping of intermediate size and large molecules and biomolecules at ultra-high resolution using single-crystal electrodes and in situ scanning tunnelling microscopy continues to disclose surprising findings. In situ scanning tunnelling spectroscopy has also recently disclosed new electrochemical conductivity features at the level of the single molecule. We overview briefly elements of this development over the last few years, with focus on three recent discoveries: (1) a new packing mode of a core monolayer target thiol, the amino acid cysteine (Cys) on Au(100)-electrodes, quite different from Cys packing on Au(111)- and Au(110)-electrodes; (2) transition of a core ferrocene in situ scanning tunnelling spectroscopy probe from stochastic single-molecule to macroscopic behaviour, a concept at the heart of nanoscience; and (3) unexpected behaviour of the large molybdenum enzyme sulfite oxidase, when going from macroscopic to single-molecule electrochemistry. We compare these studies with other recent discoveries of single-molecule protein conductivity and molecular scale inorganic nanostructures.

Original languageEnglish
Article number100670
JournalCurrent Opinion in Electrochemistry
Volume26
Number of pages10
ISSN2451-9103
DOIs
Publication statusPublished - 2021

Keywords

  • Cysteine on Au(100)
  • Scanning tunnelling spectroscopy
  • Single-entity electrochemistry
  • Stochastic conductivity of redox molecules
  • Sulfite oxidase

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