Abstract
Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.
Original language | English |
---|---|
Journal | Journal of Natural Products |
Volume | 75 |
Issue number | 10 |
Pages (from-to) | 1729-1734 |
Number of pages | 6 |
ISSN | 0163-3864 |
DOIs | |
Publication status | Published - 2012 |
Externally published | Yes |