Elaiomycins D-F, Antimicrobial and Cytotoxic Azoxides from Streptomyces sp Strain HKI0708

Ling Ding; Basile Le Sage Tchize Ndejouong; Armin Maier; Heinz-Herbert Fiebig; Christian Hertweck

doi:10.1021/np300329m

Elaiomycins D-F, Antimicrobial and Cytotoxic Azoxides from Streptomyces sp Strain HKI0708

Ling Ding, Basile Le Sage Tchize Ndejouong, Armin Maier, Heinz-Herbert Fiebig, Christian Hertweck

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.

Original language	English
Journal	Journal of Natural Products
Volume	75
Issue number	10
Pages (from-to)	1729-1734
Number of pages	6
ISSN	0163-3864
DOIs	https://doi.org/10.1021/np300329m
Publication status	Published - 2012
Externally published	Yes

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title = "Elaiomycins D-F, Antimicrobial and Cytotoxic Azoxides from Streptomyces sp Strain HKI0708",

abstract = "Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.",

author = "Ling Ding and Ndejouong, {Basile Le Sage Tchize} and Armin Maier and Heinz-Herbert Fiebig and Christian Hertweck",

year = "2012",

doi = "10.1021/np300329m",

language = "English",

volume = "75",

pages = "1729--1734",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Elaiomycins D-F, Antimicrobial and Cytotoxic Azoxides from Streptomyces sp Strain HKI0708

AU - Ding, Ling

AU - Ndejouong, Basile Le Sage Tchize

AU - Maier, Armin

AU - Fiebig, Heinz-Herbert

AU - Hertweck, Christian

PY - 2012

Y1 - 2012

N2 - Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.

AB - Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.

U2 - 10.1021/np300329m

DO - 10.1021/np300329m

M3 - Journal article

VL - 75

SP - 1729

EP - 1734

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 10

ER -

Elaiomycins D-F, Antimicrobial and Cytotoxic Azoxides from Streptomyces sp Strain HKI0708

Abstract

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