Elaiomycins D-F, Antimicrobial and Cytotoxic Azoxides from Streptomyces sp Strain HKI0708

Ling Ding, Basile Le Sage Tchize Ndejouong, Armin Maier, Heinz-Herbert Fiebig, Christian Hertweck

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.
Original languageEnglish
JournalJournal of Natural Products
Volume75
Issue number10
Pages (from-to)1729-1734
Number of pages6
ISSN0163-3864
DOIs
Publication statusPublished - 2012
Externally publishedYes

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