EFSA Panel on Food Contact Material, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 201Rev1: 2-Alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19

EFSA Publication

Research output: Book/ReportReportpeer-review

424 Downloads (Pure)

Abstract

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider in this revision 1 of Flavouring Group Evaluation 201, the additional data on genotoxicity submitted by the Industry on two substances, 2-methylpent-2-enal [FL-no: 05.090] and 2
methylcrotonaldehyde [FL-no: 05.095], from subgroup 1.1.2 of FGE.19. First the Panel concluded that genotoxicity data on [FL-no: 05.095] can be representative for the substances [FL-no: 02.174, 05.033, 05.090, 05.105, 05.107 and 05.126], but not for [FL-no: 05.130, 05.178, 09.177 and 09.931], for which it was concluded in the previous version of this FGE that the available data were insufficient to evaluate their genotoxicity. Secondly, the Panel considers that the mutagenicity hazard could not be cleared by the endpoints evaluated in the in vivo micronucleus assay submitted. The Panel therefore concluded that further data are required in order to clarify the genotoxic potential of this subgroup. The Panel considers the Comet assay with [FL-no: 05.095] as test material and
performed on liver, blood and first site of contact, as a preferred option to further investigate the genotoxicity in vivo.
Original languageEnglish
Place of PublicationParma, Italy
PublisherEuropean Food Safety Authority
Number of pages28
DOIs
Publication statusPublished - 2012
Seriesthe EFSA Journal
Number2749
Volume10(5)
ISSN1830-5458

Fingerprint

Dive into the research topics of 'EFSA Panel on Food Contact Material, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 201Rev1: 2-Alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19'. Together they form a unique fingerprint.

Cite this