Following an application from Omikron Italia S.r.l., submitted pursuant to Article 13.5 of Regulation (EC) No 1924/2006 via the Competent Authority of Italy, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous tone. The food that is a subject of the health claim, a combination of diosmin, troxerutin and hesperidin, is sufficiently characterised. The claimed effect, maintenance of normal venous tone, is a beneficial physiological effect. No human intervention studies from which conclusions could be drawn for the scientific substantiation of the claim were provided by the applicant. The Panel concludes that a cause and effect relationship has not been established between the consumption of a combination of diosmin, troxerutin and hesperidin and the maintenance of normal venous tone.