Efficient Computational Design of a Scaffold for Cartilage Cell Regeneration

Tannaz Tajsoleiman, Mohammad Jafar Abdekhodaie, Krist V. Gernaey, Ulrich Krühne*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

284 Downloads (Pure)


Due to the sensitivity of mammalian cell cultures, understanding the influence of operating conditions during a tissue generation procedure is crucial. In this regard, a detailed study of scaffold based cell culture under a perfusion flow is presented with the aid of mathematical modelling and computational fluid dynamics (CFD). With respect to the complexity of the case study, this work focuses solely on the effect of nutrient and metabolite concentrations, and the possible influence of fluid-induced shear stress on a targeted cell (cartilage) culture. The simulation set up gives the possibility of predicting the cell culture behavior under various operating conditions and scaffold designs. Thereby, the exploitation of the predictive simulation into a newly developed stochastic routine provides the opportunity of exploring improved scaffold geometry designs. This approach was applied on a common type of fibrous structure in order to increase the process efficiencies compared with the regular used formats. The suggested topology supplies a larger effective surface for cell attachment compared to the reference design while the level of shear stress is kept at the positive range of effect. Moreover, significant improvement of mass transfer is predicted for the suggested topology.
Original languageEnglish
Article number33
Issue number2
Number of pages15
Publication statusPublished - 2018


  • Tissue engineering
  • CFD simulation
  • Scaffold geometry optimization
  • Micro-bioreactor
  • Operating conditions

Fingerprint Dive into the research topics of 'Efficient Computational Design of a Scaffold for Cartilage Cell Regeneration'. Together they form a unique fingerprint.

Cite this