Efficient Bulky Phosphines for the Selective Telomerization of 1,3-Butadiene with Methanol

Mathieu J.-L. Tschan, Eduardo Garcia, Zoraida Freixa, Hélène Launay, Henk Hagen, Jordi Benet-Buchholz, Piet W. N. M. van Leeuwen

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A series of bulky phosphines containing substituted biphenyl, 2-methylnaphthyl, or 2,7-di-tert-butyl-9,9-dimethylxanthene moiety were prepared. They were used in the preparation of new monophosphine−palladium(0)−dvds complexes, which were employed as catalysts for the selective telomerization of 1,3-butadiene with methanol to obtain 1-methoxyocta-2,7-diene (1-MOD), the key intermediate in the Dow 1-octene process. Several ligands showed improved selectivity and yield compared to that of the benchmark ligand PPh3. Especially 2,7-di-tert-butyl-9,9-dimethylxanthen-4-yl-diphenylphosphine (4, “mono-xantphos”) stands out as an excellent ligand in terms of yield, selectivity, and stability.
Original languageEnglish
JournalJournal of the American Chemical Society
Issue number18
Pages (from-to)6463-6473
Publication statusPublished - 2010
Externally publishedYes


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