Efficiency of the Clinical Veterinary Diagnostic Practices and Drug Choices for Infectious Diseases in Livestock in Bangladesh

Najmul Haider, S. U. Khan, A. Islam, M. G. Osmani, M. Z. Rahman, J. H. Epstain, P. Daszak, N. Zeidner

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    Abstract

    As in most low-income countries, adequate laboratory facilities are not available in Bangladesh to assist veterinarians in diagnosing animal diseases. We aimed to determine the efficiency of veterinary diagnoses for two common ruminant diseases in Bangladesh: Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD). We conducted the study from May 2009 to August 2010 in three government veterinary hospitals where veterinarians collected samples from sick livestock and recorded the presumptive diagnosis on the basis of clinical presentations. Samples were tested for PPR and FMD using real-time RT-PCR. We estimated the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the presumptive diagnoses when compared to laboratory tests. We tested 539 goats for PPR and 340 cattle and goats for FMD. Our results indicate that the veterinarians' presumptive diagnoses were different from laboratory findings for both PPR (P < 0.05) and FMD (P < 0.05). The overall sensitivity of the presumptive clinical diagnoses was 54% (95% CI: 47–61%) while specificity was 81% (95% CI: 78–84%) compared to real-time RT-PCR tests. The kappa value obtained in our validation process for PPR (kappa: 0.25) and FMD (kappa 0.36) indicated a poor performance of the presumptive diagnoses. Most of the animals (93%) were treated with antibiotics. Our findings indicate that veterinarians can detect animals not infected with FMD or PPR but miss the true cases. The clinical competency of these veterinarians needs to be improved and access to laboratory diagnostic facilities could help veterinarians to improve the diagnostics and outcomes. The rational use of antibiotics by veterinarians in animals must be ensured.
    Original languageEnglish
    JournalTransboundary and Emerging Diseases
    Volume64
    Issue number4
    Pages (from-to)1329-1333
    ISSN1865-1674
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Clinical diagnostic practices
    • Presumptive diagnoses
    • Sensitivity
    • Specificity
    • Bangladesh
    • PPR
    • FMD

    Cite this

    Haider, Najmul ; Khan, S. U. ; Islam, A. ; Osmani, M. G. ; Rahman, M. Z. ; Epstain, J. H. ; Daszak, P. ; Zeidner, N. / Efficiency of the Clinical Veterinary Diagnostic Practices and Drug Choices for Infectious Diseases in Livestock in Bangladesh. In: Transboundary and Emerging Diseases. 2017 ; Vol. 64, No. 4. pp. 1329-1333.
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    title = "Efficiency of the Clinical Veterinary Diagnostic Practices and Drug Choices for Infectious Diseases in Livestock in Bangladesh",
    abstract = "As in most low-income countries, adequate laboratory facilities are not available in Bangladesh to assist veterinarians in diagnosing animal diseases. We aimed to determine the efficiency of veterinary diagnoses for two common ruminant diseases in Bangladesh: Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD). We conducted the study from May 2009 to August 2010 in three government veterinary hospitals where veterinarians collected samples from sick livestock and recorded the presumptive diagnosis on the basis of clinical presentations. Samples were tested for PPR and FMD using real-time RT-PCR. We estimated the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the presumptive diagnoses when compared to laboratory tests. We tested 539 goats for PPR and 340 cattle and goats for FMD. Our results indicate that the veterinarians' presumptive diagnoses were different from laboratory findings for both PPR (P < 0.05) and FMD (P < 0.05). The overall sensitivity of the presumptive clinical diagnoses was 54{\%} (95{\%} CI: 47–61{\%}) while specificity was 81{\%} (95{\%} CI: 78–84{\%}) compared to real-time RT-PCR tests. The kappa value obtained in our validation process for PPR (kappa: 0.25) and FMD (kappa 0.36) indicated a poor performance of the presumptive diagnoses. Most of the animals (93{\%}) were treated with antibiotics. Our findings indicate that veterinarians can detect animals not infected with FMD or PPR but miss the true cases. The clinical competency of these veterinarians needs to be improved and access to laboratory diagnostic facilities could help veterinarians to improve the diagnostics and outcomes. The rational use of antibiotics by veterinarians in animals must be ensured.",
    keywords = "Clinical diagnostic practices, Presumptive diagnoses, Sensitivity, Specificity, Bangladesh, PPR, FMD",
    author = "Najmul Haider and Khan, {S. U.} and A. Islam and Osmani, {M. G.} and Rahman, {M. Z.} and Epstain, {J. H.} and P. Daszak and N. Zeidner",
    year = "2017",
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    Haider, N, Khan, SU, Islam, A, Osmani, MG, Rahman, MZ, Epstain, JH, Daszak, P & Zeidner, N 2017, 'Efficiency of the Clinical Veterinary Diagnostic Practices and Drug Choices for Infectious Diseases in Livestock in Bangladesh', Transboundary and Emerging Diseases, vol. 64, no. 4, pp. 1329-1333. https://doi.org/10.1111/tbed.12502

    Efficiency of the Clinical Veterinary Diagnostic Practices and Drug Choices for Infectious Diseases in Livestock in Bangladesh. / Haider, Najmul; Khan, S. U.; Islam, A.; Osmani, M. G.; Rahman, M. Z.; Epstain, J. H.; Daszak, P.; Zeidner, N.

    In: Transboundary and Emerging Diseases, Vol. 64, No. 4, 2017, p. 1329-1333.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Efficiency of the Clinical Veterinary Diagnostic Practices and Drug Choices for Infectious Diseases in Livestock in Bangladesh

    AU - Haider, Najmul

    AU - Khan, S. U.

    AU - Islam, A.

    AU - Osmani, M. G.

    AU - Rahman, M. Z.

    AU - Epstain, J. H.

    AU - Daszak, P.

    AU - Zeidner, N.

    PY - 2017

    Y1 - 2017

    N2 - As in most low-income countries, adequate laboratory facilities are not available in Bangladesh to assist veterinarians in diagnosing animal diseases. We aimed to determine the efficiency of veterinary diagnoses for two common ruminant diseases in Bangladesh: Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD). We conducted the study from May 2009 to August 2010 in three government veterinary hospitals where veterinarians collected samples from sick livestock and recorded the presumptive diagnosis on the basis of clinical presentations. Samples were tested for PPR and FMD using real-time RT-PCR. We estimated the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the presumptive diagnoses when compared to laboratory tests. We tested 539 goats for PPR and 340 cattle and goats for FMD. Our results indicate that the veterinarians' presumptive diagnoses were different from laboratory findings for both PPR (P < 0.05) and FMD (P < 0.05). The overall sensitivity of the presumptive clinical diagnoses was 54% (95% CI: 47–61%) while specificity was 81% (95% CI: 78–84%) compared to real-time RT-PCR tests. The kappa value obtained in our validation process for PPR (kappa: 0.25) and FMD (kappa 0.36) indicated a poor performance of the presumptive diagnoses. Most of the animals (93%) were treated with antibiotics. Our findings indicate that veterinarians can detect animals not infected with FMD or PPR but miss the true cases. The clinical competency of these veterinarians needs to be improved and access to laboratory diagnostic facilities could help veterinarians to improve the diagnostics and outcomes. The rational use of antibiotics by veterinarians in animals must be ensured.

    AB - As in most low-income countries, adequate laboratory facilities are not available in Bangladesh to assist veterinarians in diagnosing animal diseases. We aimed to determine the efficiency of veterinary diagnoses for two common ruminant diseases in Bangladesh: Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD). We conducted the study from May 2009 to August 2010 in three government veterinary hospitals where veterinarians collected samples from sick livestock and recorded the presumptive diagnosis on the basis of clinical presentations. Samples were tested for PPR and FMD using real-time RT-PCR. We estimated the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the presumptive diagnoses when compared to laboratory tests. We tested 539 goats for PPR and 340 cattle and goats for FMD. Our results indicate that the veterinarians' presumptive diagnoses were different from laboratory findings for both PPR (P < 0.05) and FMD (P < 0.05). The overall sensitivity of the presumptive clinical diagnoses was 54% (95% CI: 47–61%) while specificity was 81% (95% CI: 78–84%) compared to real-time RT-PCR tests. The kappa value obtained in our validation process for PPR (kappa: 0.25) and FMD (kappa 0.36) indicated a poor performance of the presumptive diagnoses. Most of the animals (93%) were treated with antibiotics. Our findings indicate that veterinarians can detect animals not infected with FMD or PPR but miss the true cases. The clinical competency of these veterinarians needs to be improved and access to laboratory diagnostic facilities could help veterinarians to improve the diagnostics and outcomes. The rational use of antibiotics by veterinarians in animals must be ensured.

    KW - Clinical diagnostic practices

    KW - Presumptive diagnoses

    KW - Sensitivity

    KW - Specificity

    KW - Bangladesh

    KW - PPR

    KW - FMD

    U2 - 10.1111/tbed.12502

    DO - 10.1111/tbed.12502

    M3 - Journal article

    C2 - 27062143

    VL - 64

    SP - 1329

    EP - 1333

    JO - Transboundary and Emerging Diseases

    JF - Transboundary and Emerging Diseases

    SN - 1865-1674

    IS - 4

    ER -