Efficacy of electrochemically activated water solution in gingivitis treatment

Truong Vo, Dinh-Toi Chu, Duc Duong, Van Bui, Minh Son Tong, Thi Nguyen, Quynh Le, Khanh Hoang Nguyen, Van-Huy Pham, Thien Chu-Dinh*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


Mouthwash is one of the most commonly oral healthcare products for prevention and treatment of gum diseases. Dr. ECA is a disinfectant solution manufactured by a Vietnamese company and has been licensed for oral healthcare, but its effect on gingivitis is still unclear. To evaluate the effectiveness of this product in the treatment of gingivitis, we conducted a clinical study in 60 students diagnosed with gingivitis to compare the results of gingivitis treatment using Dr. ECA and a control mouthwash (a demonstrated anti-gingivitis product). The data showed that in the treated group, the rate of good Gingivitis Index (GI) before treatment was 46.67%, but after 2 and 4 weeks of using Dr. ECA that rate was increased to 96.67% and 100%, respectively. The percentage of patients with bleeding on probing was 63.33% but declined sharply after 2 weeks of treatment to 6.67%, and further reduced to 3.33% after 4 weeks of treatment. The treatment outcomes in were similar in the Dr. ECA treated group and control one with no statistically significant difference. Our results suggest that the electrolyte saline solution Dr. ECA is effective in treating gingivitis. Its effects are similar to other mouthwash products that had been approved and marketed.
Original languageEnglish
JournalJournal of Pharmaceutical Investigation
Issue number3
Pages (from-to)323-329
Publication statusPublished - 2019


  • Biomedicine
  • Biomedicine, general
  • Biomedical and Life Sciences
  • Mouthwash
  • Electrochemically activated water solutions
  • Dr. ECA
  • Gingivitis

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