Effects of quorum-sensing on immunoglobulin G responses in a rat model of chronic lung infection with Pseudomonas aeruginosa

H. WU, Z.J. Song, Michael Christian Givskov, N. Høiby

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Levels of serum antibodies against Pseudomonas aeruginosa were observed for 106 days in a rat model of chronic lung infection. Significantly weaker responses of serum IgG and IgG1 and a lower ratio of IgGI/IgG2a were found in the rats infected with the quorum-signal-deficient mutant, PAO1 (rhlI, lasI), compared with the wild-type PAO1. Four out of 15 rats infected with wild-type PAO1 contained bacteria in the lungs on day 106, whereas no bacteria were found in the mutant PAO1 group. The results indicate that quorum signals contribute to the persistence of the infection and influence the immune response.
    Original languageEnglish
    JournalMicrobes and Infection
    Volume6
    Pages (from-to)34-37
    Publication statusPublished - 2004

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