Effects of prenatal exposure to xylene on postnatal development and behavior in rats

Ulla Hass; S. P. Lund; L. Simonsen; A. S. Fries

doi:10.1016/0892-0362(94)00093-S

Effects of prenatal exposure to xylene on postnatal development and behavior in rats

Ulla Hass
, S. P. Lund
, L. Simonsen
, A. S. Fries

National Food Institute

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The effects of prenatal exposure to the organic solvent xylene (dimethylbenzene, GAS-no 1330-20-7) on postnatal development and behavior in rats were studied. Pregnant rats (Mol:WIST) were exposed to 500 ppm technical xylene 6 h per day on gestation days 7-20. The dose level was selected so as not to induce maternal toxicity or decrease the viability of offspring. In the exposed offspring, a delay in the ontogeny of the air righting reflex, a lower absolute brain weight, and impaired performance in behavioral tests for neuromotor abilities (Rotarod) and for learning and memory (Morris water maze) were found. Generally, the effects were most marked in the female offspring.

Original language	English
Journal	Neurotoxicology and Teratology
Volume	17
Issue number	3
Pages (from-to)	341-349
ISSN	0892-0362
DOIs	https://doi.org/10.1016/0892-0362(94)00093-S
Publication status	Published - 1995

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title = "Effects of prenatal exposure to xylene on postnatal development and behavior in rats",

abstract = "The effects of prenatal exposure to the organic solvent xylene (dimethylbenzene, GAS-no 1330-20-7) on postnatal development and behavior in rats were studied. Pregnant rats (Mol:WIST) were exposed to 500 ppm technical xylene 6 h per day on gestation days 7-20. The dose level was selected so as not to induce maternal toxicity or decrease the viability of offspring. In the exposed offspring, a delay in the ontogeny of the air righting reflex, a lower absolute brain weight, and impaired performance in behavioral tests for neuromotor abilities (Rotarod) and for learning and memory (Morris water maze) were found. Generally, the effects were most marked in the female offspring.",

author = "Ulla Hass and Lund, \{S. P.\} and L. Simonsen and Fries, \{A. S.\}",

year = "1995",

doi = "10.1016/0892-0362(94)00093-S",

language = "English",

volume = "17",

pages = "341--349",

journal = "Neurotoxicology and Teratology",

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TY - JOUR

T1 - Effects of prenatal exposure to xylene on postnatal development and behavior in rats

AU - Hass, Ulla

AU - Lund, S. P.

AU - Simonsen, L.

AU - Fries, A. S.

PY - 1995

Y1 - 1995

N2 - The effects of prenatal exposure to the organic solvent xylene (dimethylbenzene, GAS-no 1330-20-7) on postnatal development and behavior in rats were studied. Pregnant rats (Mol:WIST) were exposed to 500 ppm technical xylene 6 h per day on gestation days 7-20. The dose level was selected so as not to induce maternal toxicity or decrease the viability of offspring. In the exposed offspring, a delay in the ontogeny of the air righting reflex, a lower absolute brain weight, and impaired performance in behavioral tests for neuromotor abilities (Rotarod) and for learning and memory (Morris water maze) were found. Generally, the effects were most marked in the female offspring.

AB - The effects of prenatal exposure to the organic solvent xylene (dimethylbenzene, GAS-no 1330-20-7) on postnatal development and behavior in rats were studied. Pregnant rats (Mol:WIST) were exposed to 500 ppm technical xylene 6 h per day on gestation days 7-20. The dose level was selected so as not to induce maternal toxicity or decrease the viability of offspring. In the exposed offspring, a delay in the ontogeny of the air righting reflex, a lower absolute brain weight, and impaired performance in behavioral tests for neuromotor abilities (Rotarod) and for learning and memory (Morris water maze) were found. Generally, the effects were most marked in the female offspring.

U2 - 10.1016/0892-0362(94)00093-S

DO - 10.1016/0892-0362(94)00093-S

M3 - Journal article

SN - 0892-0362

VL - 17

SP - 341

EP - 349

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

IS - 3

ER -

Effects of prenatal exposure to xylene on postnatal development and behavior in rats

Abstract

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