TY - JOUR
T1 - Effects of prenatal exposure to toluene on postnatal development and behavior in rats
AU - Hougaard, K. S.
AU - Hass, Ulla
AU - Lund, S. P.
AU - Simonsen, L.
PY - 1999
Y1 - 1999
N2 - Development and neurobehavioral effects of prenatal exposure to toluene (CAS 108-88-3) were studied after exposing pregnant rats (Mol:WIST) to 1800 ppm of the solvent for 6 h daily on days 7-20 of gestation. Body weights of exposed offspring were lower until day 10 after parturition. Neurobehavioral evaluation of the pups revealed no effects on motor function (rotarod), activity level (open field), acoustic startle, and prepulse inhibition. Measurements of hearing function using auditory brain stem response revealed small effects in male-exposed offspring. Performance in a Morris water maze during initial learning gave some indications of impaired cognitive functions, which was confirmed during further testing, especially in reversal and new learning. Effects on cognitive functions seemed most marked in female offspring. (C) 1999 Elsevier Science Inc. All rights reserved.
AB - Development and neurobehavioral effects of prenatal exposure to toluene (CAS 108-88-3) were studied after exposing pregnant rats (Mol:WIST) to 1800 ppm of the solvent for 6 h daily on days 7-20 of gestation. Body weights of exposed offspring were lower until day 10 after parturition. Neurobehavioral evaluation of the pups revealed no effects on motor function (rotarod), activity level (open field), acoustic startle, and prepulse inhibition. Measurements of hearing function using auditory brain stem response revealed small effects in male-exposed offspring. Performance in a Morris water maze during initial learning gave some indications of impaired cognitive functions, which was confirmed during further testing, especially in reversal and new learning. Effects on cognitive functions seemed most marked in female offspring. (C) 1999 Elsevier Science Inc. All rights reserved.
U2 - 10.1016/S0892-0362(98)00053-1
DO - 10.1016/S0892-0362(98)00053-1
M3 - Journal article
SN - 0892-0362
VL - 21
SP - 241
EP - 450
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
IS - 3
ER -