TY - JOUR
T1 - Effects of perinatal ethinyl estradiol exposure in male and female Wistar rats
AU - Mandrup, Karen
AU - Jacobsen, Pernille Rosenskjold
AU - Isling, Louise Krag
AU - Petersen, Marta Axelstad
AU - Sørensen, Karin Dreisig
AU - Hadrup, Niels
AU - Vinggaard, Anne Marie
AU - Hass, Ulla
AU - Boberg, Julie
PY - 2013
Y1 - 2013
N2 - Perinatal exposure to endocrine disrupting chemicals with estrogenic activity can adversely affect reproductive development, but few studies evaluating estrogen-sensitive endpoints have been performed in Wistar rats. Therefore, time-mated Wistar rats (n=10) were gavaged during gestation and lactation with 0, 5, 15 or 50μg/kg bw/day of ethinyl estradiol.This potent estrogen was found to induce an increased number of nipples and reduced ovary weight in female offspring. Malformations of female genitalia were found in young as well as adult offspring, as an increased AGD was seen at birth and a deeper urethral slit length was seen in adulthood. In prepubertal male offspring, estrogen-regulated gene expression in ventral prostate was increased dose-dependently and a decreased ventral prostate weight was seen at 15μg/kg.Female external sexual characteristics and prostate development were found to be targets for exposure to estrogenic compounds and may be of interest in studies on estrogenic environmental compounds.
AB - Perinatal exposure to endocrine disrupting chemicals with estrogenic activity can adversely affect reproductive development, but few studies evaluating estrogen-sensitive endpoints have been performed in Wistar rats. Therefore, time-mated Wistar rats (n=10) were gavaged during gestation and lactation with 0, 5, 15 or 50μg/kg bw/day of ethinyl estradiol.This potent estrogen was found to induce an increased number of nipples and reduced ovary weight in female offspring. Malformations of female genitalia were found in young as well as adult offspring, as an increased AGD was seen at birth and a deeper urethral slit length was seen in adulthood. In prepubertal male offspring, estrogen-regulated gene expression in ventral prostate was increased dose-dependently and a decreased ventral prostate weight was seen at 15μg/kg.Female external sexual characteristics and prostate development were found to be targets for exposure to estrogenic compounds and may be of interest in studies on estrogenic environmental compounds.
KW - Endocrine disruption
KW - Estrogen
KW - Anogenital distance
KW - Nipples
KW - Mammary gland
KW - Gene expression
KW - Onset of puberty
KW - Genital malformations
U2 - 10.1016/j.reprotox.2013.09.001
DO - 10.1016/j.reprotox.2013.09.001
M3 - Journal article
C2 - 24036065
SN - 0890-6238
VL - 42
SP - 180
EP - 191
JO - Reproductive Toxicology
JF - Reproductive Toxicology
ER -