Effects of perfluorononanoic acid (PFNA) on the metabolic profiling of rat serum by UHPLC-ESI-Q-TOF MSMS

Kasper Skov, Niels Hadrup, Anne Marie Vestergaard, Jørn Smedsgaard, Henrik Lauritz Frandsen

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Abstract

Endocrine disrupting chemicals are compounds which interfere with normal hormone homeostasis. So far the main concern has been the effect on the reproduction and development. This study has been conducted to find the effect of EDC on the human metabolome, using LC high resolution mass spectrometry and chemical separation of plasma metabolites it is possible to find the difference in the plasma metabolome affected by EDC. The study was conducted given a group of rats an EDC and another group a combination of EDC’s and CYP inhibitors.
Original languageEnglish
Publication date2013
Number of pages1
Publication statusPublished - 2013
Event9th International Conference of the Metabolomics Society - Glasgow, United Kingdom
Duration: 1 Jul 20134 Jul 2013
http://www.metabolomics2013.org/

Conference

Conference9th International Conference of the Metabolomics Society
CountryUnited Kingdom
CityGlasgow
Period01/07/201304/07/2013
Internet address

Bibliographical note

Endocrine disrupting chemicals are compounds which interfere with normal hormone homeostasis. So far the main concern has been the effect on the reproduction and development. This study has been conducted to find the effect of EDC on the human metabolome, using LC high resolution mass spectrometry and chemical separation of plasma metabolites it is possible to find the difference in the plasma metabolome affected by EDC. The study was conducted given a group of rats an EDC and another group a combination of EDC’s and CYP inhibitors.

Cite this

Skov, K., Hadrup, N., Vestergaard, A. M., Smedsgaard, J., & Frandsen, H. L. (2013). Effects of perfluorononanoic acid (PFNA) on the metabolic profiling of rat serum by UHPLC-ESI-Q-TOF MSMS. Poster session presented at 9th International Conference of the Metabolomics Society, Glasgow, United Kingdom.