Effects of Oral Administration of Specific Antibodies to Rainbow trout Oncorhynchus mykiss

Michael Engelbrecht Nielsen, Kurt Buchmann

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A new product called oralized fish serum concentrate (OFSC) was evaluated for a possible effect against various bacterial pathogens in rainbow trout. The OFSC produced from immune trout sera was found to contain fully functional antibodies and complement component C3. The antibodies detected in the serum concentrate were specific to Vibrio anguillarum (O1 and 02) and Aeromonas salmonicida, which had been used for vaccination of the fish prior to serum collection. The functionality of the specific antibodies in OFSC was not reduced after 6 wk storage at -20 C, 5 C, and 20 C. The serum was mixed with commercial trout feed and used for feeding rainbow trout fry (first feed period). After oral delivery of OFSC to rainbow trout for 1 mo, samples of gut content and gut tissue contained functional antibodies. In gutted fish no functional antibodies were found. This suggests that antibodies from OFSC are unable to be transferred across the gut wall in a functional state. Oral administration of OFSC did not increase survival of rainbow trout in an immersion challenge with Vibrio anguillarum.
Original languageEnglish
JournalJournal of the World Aquaculture Society
Volume34
Issue number1
Pages (from-to)11-17
ISSN0893-8849
DOIs
Publication statusPublished - 2003
Externally publishedYes

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