Effects of network resolution on topological properties of human neocortex

Rafael Romero-Garcia, Mercedes Atienza, Line Katrine Harder Clemmensen, Jose L. Cantero

    Research output: Contribution to journalJournal articleResearchpeer-review

    469 Downloads (Pure)

    Abstract

    Graph theoretical analyses applied to neuroimaging datasets have provided valuable insights into the large-scale anatomical organization of the human neocortex. Most of these studies were performed with different cortical scales leading to cortical networks with different levels of small-world organization. The present study investigates how resolution of thickness-based cortical scales impacts on topological properties of human anatomical cortical networks. To this end, we designed a novel approach aimed at determining the best trade-off between small-world attributes of anatomical cortical networks and the number of cortical regions included in the scale. Results revealed that schemes comprising 540–599 regions (surface areas spanning between 250 and 275mm2) at sparsities below 10% showed a superior balance between small-world organization and the size of the cortical scale employed. Furthermore, we found that the cortical scale representing the best trade-off (599 regions) was more resilient to targeted attacks than atlas-based schemes (Desikan–Killiany atlas, 66 regions) and, most importantly, it did not differ that much from the finest cortical scale tested in the present study (1494 regions). In summary, our study confirms that topological organization of anatomical cortical networks varies with both sparsity and resolution of cortical scale, and it further provides a novel methodological framework aimed at identifying cortical schemes that maximize small-worldness with the lowest scale resolution possible.
    Original languageEnglish
    JournalNeuroImage
    Volume59
    Issue number4
    Pages (from-to)3522-3532
    ISSN1053-8119
    DOIs
    Publication statusPublished - 2012

    Bibliographical note

    NOTICE: the attached postprint is the author’s version of a work that was accepted for publication in NeuroImage. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in the document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in NeuroImage, [Volume 59, Issue 4, 15 February 2012] 10.1016/j.neuroimage.2011.10.086

    Keywords

    • Cortical scale
    • Cortical thickness
    • Small-world properties
    • Cortical networks
    • Structural connectivity

    Fingerprint

    Dive into the research topics of 'Effects of network resolution on topological properties of human neocortex'. Together they form a unique fingerprint.

    Cite this