TY - JOUR
T1 - Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism
AU - Mandrup, Camilla M
AU - Egelund, Jon
AU - Nyberg, Michael
AU - Enevoldsen, Lotte Hahn
AU - Kjær, Andreas
AU - Clemmensen, Andreas E
AU - Christensen, Anders Nymark
AU - Suetta, Charlotte
AU - Frikke-Schmidt, Ruth
AU - Steenberg, Dorte Enggaard
AU - Wojtaszewski, Jørgen F P
AU - Hellsten, Ylva
AU - Stallknecht, Bente M
PY - 2018
Y1 - 2018
N2 - To investigate peripheral insulin sensitivity and skeletal muscle glucose metabolism in premenopausal and postmenopausal women, and evaluate whether exercise training benefits are maintained after menopause. Sedentary, healthy, normal-weight, late premenopausal (n = 21), and early postmenopausal (n = 20) women were included in a 3-month high-intensity exercise training intervention. Body composition was assessed by magnetic resonance imaging and dual-energy x-ray absorptiometry, whole body glucose disposal rate (GDR) by hyperinsulinemic euglycemic clamp (40 mU/m/min), and femoral muscle glucose uptake by positron emission tomography/computed tomography, using the glucose analog fluorodeoxyglucose, expressed as estimated metabolic rate (eMR). Insulin signaling was investigated in muscle biopsies. Age difference between groups was 4.5 years, and no difference was observed in body composition. Training increased lean body mass (estimate [95% confidence interval] 0.5 [0.2-0.9] kg, P
AB - To investigate peripheral insulin sensitivity and skeletal muscle glucose metabolism in premenopausal and postmenopausal women, and evaluate whether exercise training benefits are maintained after menopause. Sedentary, healthy, normal-weight, late premenopausal (n = 21), and early postmenopausal (n = 20) women were included in a 3-month high-intensity exercise training intervention. Body composition was assessed by magnetic resonance imaging and dual-energy x-ray absorptiometry, whole body glucose disposal rate (GDR) by hyperinsulinemic euglycemic clamp (40 mU/m/min), and femoral muscle glucose uptake by positron emission tomography/computed tomography, using the glucose analog fluorodeoxyglucose, expressed as estimated metabolic rate (eMR). Insulin signaling was investigated in muscle biopsies. Age difference between groups was 4.5 years, and no difference was observed in body composition. Training increased lean body mass (estimate [95% confidence interval] 0.5 [0.2-0.9] kg, P
KW - Glucose disposal
KW - Insulin sensitivity
KW - Insulin signaling
KW - Menopause
KW - Physical activity
KW - Journal Article
U2 - 10.1097/GME.0000000000000981
DO - 10.1097/GME.0000000000000981
M3 - Journal article
C2 - 28953212
SN - 1072-3714
VL - 25
JO - Menopause
JF - Menopause
IS - 2
ER -