Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism

Camilla M Mandrup*, Jon Egelund, Michael Nyberg, Lotte Hahn Enevoldsen, Andreas Kjær, Andreas E Clemmensen, Anders Nymark Christensen, Charlotte Suetta, Ruth Frikke-Schmidt, Dorte Enggaard Steenberg, Jørgen F P Wojtaszewski, Ylva Hellsten, Bente M Stallknecht

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


To investigate peripheral insulin sensitivity and skeletal muscle glucose metabolism in premenopausal and postmenopausal women, and evaluate whether exercise training benefits are maintained after menopause. Sedentary, healthy, normal-weight, late premenopausal (n = 21), and early postmenopausal (n = 20) women were included in a 3-month high-intensity exercise training intervention. Body composition was assessed by magnetic resonance imaging and dual-energy x-ray absorptiometry, whole body glucose disposal rate (GDR) by hyperinsulinemic euglycemic clamp (40 mU/m/min), and femoral muscle glucose uptake by positron emission tomography/computed tomography, using the glucose analog fluorodeoxyglucose, expressed as estimated metabolic rate (eMR). Insulin signaling was investigated in muscle biopsies. Age difference between groups was 4.5 years, and no difference was observed in body composition. Training increased lean body mass (estimate [95% confidence interval] 0.5 [0.2-0.9] kg, P 
Original languageEnglish
Issue number2
Number of pages11
Publication statusPublished - 2018


  • Glucose disposal
  • Insulin sensitivity
  • Insulin signaling
  • Menopause
  • Physical activity
  • Journal Article


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