Effects of lung exposure to carbon nanotubes on female fertility and pregnancy. A study in mice

Research output: Contribution to journalConference article – Annual report year: 2013Researchpeer-review

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Effects of lung exposure to carbon nanotubes on female fertility and pregnancy. A study in mice. / Hougaard, Karin S.; Jackson, Petra; Kyjovska, Zdenka O.; Birkedal, Renie K.; De Temmerman, Pieter-Jan; Brunelli, Andrea; Verleysen, Eveline; Madsen, Anne Mette; Saber, Anne T.; Pojana, Giulio; Mast, Jan; Marcomini, Antonio; Jensen, Keld A.; Wallin, Håkan; Szarek, Józef; Mortensen, Alicja; Vogel, Ulla.

In: Reproductive Toxicology, Vol. 41, No. SI, 2013, p. 86-97.

Research output: Contribution to journalConference article – Annual report year: 2013Researchpeer-review

Harvard

Hougaard, KS, Jackson, P, Kyjovska, ZO, Birkedal, RK, De Temmerman, P-J, Brunelli, A, Verleysen, E, Madsen, AM, Saber, AT, Pojana, G, Mast, J, Marcomini, A, Jensen, KA, Wallin, H, Szarek, J, Mortensen, A & Vogel, U 2013, 'Effects of lung exposure to carbon nanotubes on female fertility and pregnancy. A study in mice', Reproductive Toxicology, vol. 41, no. SI, pp. 86-97. https://doi.org/10.1016/j.reprotox.2013.05.006

APA

Hougaard, K. S., Jackson, P., Kyjovska, Z. O., Birkedal, R. K., De Temmerman, P-J., Brunelli, A., ... Vogel, U. (2013). Effects of lung exposure to carbon nanotubes on female fertility and pregnancy. A study in mice. Reproductive Toxicology, 41(SI), 86-97. https://doi.org/10.1016/j.reprotox.2013.05.006

CBE

Hougaard KS, Jackson P, Kyjovska ZO, Birkedal RK, De Temmerman P-J, Brunelli A, Verleysen E, Madsen AM, Saber AT, Pojana G, Mast J, Marcomini A, Jensen KA, Wallin H, Szarek J, Mortensen A, Vogel U. 2013. Effects of lung exposure to carbon nanotubes on female fertility and pregnancy. A study in mice. Reproductive Toxicology. 41(SI):86-97. https://doi.org/10.1016/j.reprotox.2013.05.006

MLA

Vancouver

Author

Hougaard, Karin S. ; Jackson, Petra ; Kyjovska, Zdenka O. ; Birkedal, Renie K. ; De Temmerman, Pieter-Jan ; Brunelli, Andrea ; Verleysen, Eveline ; Madsen, Anne Mette ; Saber, Anne T. ; Pojana, Giulio ; Mast, Jan ; Marcomini, Antonio ; Jensen, Keld A. ; Wallin, Håkan ; Szarek, Józef ; Mortensen, Alicja ; Vogel, Ulla. / Effects of lung exposure to carbon nanotubes on female fertility and pregnancy. A study in mice. In: Reproductive Toxicology. 2013 ; Vol. 41, No. SI. pp. 86-97.

Bibtex

@inproceedings{c6f562e03cf547a98a084564a8bc8246,
title = "Effects of lung exposure to carbon nanotubes on female fertility and pregnancy. A study in mice",
abstract = "We studied the effects of preconceptional exposure to multiwalled carbon nanotubes (MWCNTs): mature, female C57BL/6J mice were intratracheally instilled with 67μg NM-400 MWCNT, and the following day co-housed with mature males, in breeding pairs. Time to delivery of the first litter, litter parameters, maternal inflammation and histopathology of lung and liver were recorded. In male offspring, locomotor activity, startle response, and daily sperm production (DSP) were assessed. In the dams, lung and liver bore evidence of MWCNT exposure when assessed 6 weeks and 4 months after exposure. A short delay in the delivery of the first litter was observed in exposed females. Litter parameters, behavior and DSP were similar in control and exposed groups. In conclusion, instillation of a single dose of MWCNT induced long lasting pathological changes in dam lung and liver. Theoretically, lung inflammation due to particle exposure could interfere with female reproductive parameters. Whether the observed lag in delivery of a first litter was in fact caused by exposure to MWCNT should be addressed in a study designed specifically to elucidate effects on the early processes involved in establishment of pregnancy. Exposure was not associated with changes in the assessed gestational or offspring parameters.",
keywords = "Multiwalled carbon nanotubes, Pregnancy, Developmental toxicity, Reproductive toxicity, Nanotoxicology, Lung and liver pathology",
author = "Hougaard, {Karin S.} and Petra Jackson and Kyjovska, {Zdenka O.} and Birkedal, {Renie K.} and {De Temmerman}, Pieter-Jan and Andrea Brunelli and Eveline Verleysen and Madsen, {Anne Mette} and Saber, {Anne T.} and Giulio Pojana and Jan Mast and Antonio Marcomini and Jensen, {Keld A.} and H{\aa}kan Wallin and J{\'o}zef Szarek and Alicja Mortensen and Ulla Vogel",
year = "2013",
doi = "10.1016/j.reprotox.2013.05.006",
language = "English",
volume = "41",
pages = "86--97",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier Inc",
number = "SI",

}

RIS

TY - GEN

T1 - Effects of lung exposure to carbon nanotubes on female fertility and pregnancy. A study in mice

AU - Hougaard, Karin S.

AU - Jackson, Petra

AU - Kyjovska, Zdenka O.

AU - Birkedal, Renie K.

AU - De Temmerman, Pieter-Jan

AU - Brunelli, Andrea

AU - Verleysen, Eveline

AU - Madsen, Anne Mette

AU - Saber, Anne T.

AU - Pojana, Giulio

AU - Mast, Jan

AU - Marcomini, Antonio

AU - Jensen, Keld A.

AU - Wallin, Håkan

AU - Szarek, Józef

AU - Mortensen, Alicja

AU - Vogel, Ulla

PY - 2013

Y1 - 2013

N2 - We studied the effects of preconceptional exposure to multiwalled carbon nanotubes (MWCNTs): mature, female C57BL/6J mice were intratracheally instilled with 67μg NM-400 MWCNT, and the following day co-housed with mature males, in breeding pairs. Time to delivery of the first litter, litter parameters, maternal inflammation and histopathology of lung and liver were recorded. In male offspring, locomotor activity, startle response, and daily sperm production (DSP) were assessed. In the dams, lung and liver bore evidence of MWCNT exposure when assessed 6 weeks and 4 months after exposure. A short delay in the delivery of the first litter was observed in exposed females. Litter parameters, behavior and DSP were similar in control and exposed groups. In conclusion, instillation of a single dose of MWCNT induced long lasting pathological changes in dam lung and liver. Theoretically, lung inflammation due to particle exposure could interfere with female reproductive parameters. Whether the observed lag in delivery of a first litter was in fact caused by exposure to MWCNT should be addressed in a study designed specifically to elucidate effects on the early processes involved in establishment of pregnancy. Exposure was not associated with changes in the assessed gestational or offspring parameters.

AB - We studied the effects of preconceptional exposure to multiwalled carbon nanotubes (MWCNTs): mature, female C57BL/6J mice were intratracheally instilled with 67μg NM-400 MWCNT, and the following day co-housed with mature males, in breeding pairs. Time to delivery of the first litter, litter parameters, maternal inflammation and histopathology of lung and liver were recorded. In male offspring, locomotor activity, startle response, and daily sperm production (DSP) were assessed. In the dams, lung and liver bore evidence of MWCNT exposure when assessed 6 weeks and 4 months after exposure. A short delay in the delivery of the first litter was observed in exposed females. Litter parameters, behavior and DSP were similar in control and exposed groups. In conclusion, instillation of a single dose of MWCNT induced long lasting pathological changes in dam lung and liver. Theoretically, lung inflammation due to particle exposure could interfere with female reproductive parameters. Whether the observed lag in delivery of a first litter was in fact caused by exposure to MWCNT should be addressed in a study designed specifically to elucidate effects on the early processes involved in establishment of pregnancy. Exposure was not associated with changes in the assessed gestational or offspring parameters.

KW - Multiwalled carbon nanotubes

KW - Pregnancy

KW - Developmental toxicity

KW - Reproductive toxicity

KW - Nanotoxicology

KW - Lung and liver pathology

U2 - 10.1016/j.reprotox.2013.05.006

DO - 10.1016/j.reprotox.2013.05.006

M3 - Conference article

VL - 41

SP - 86

EP - 97

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

IS - SI

ER -